Evidence map›Paper›PMID 36030603›Full record

ArticleThe Journal of surgical research2022

Gastric Aspiration and Ventilator-Induced Model of Acute Respiratory Distress Syndrome in Swine.

Evan P Rotar, Nathan S Haywood, J Hunter Mehaffey, Dustin T Money, Huy Q Ta, Mark H Stoler, Nicholas R Teman, Victor E Laubach, Irving L Kron, Mark E Roeser

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of surgical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Evan P RotarDepartment of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia.
Nathan S HaywoodDepartment of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia.
J Hunter MehaffeyDepartment of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia.
Dustin T MoneyDepartment of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia.
Huy Q TaDepartment of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia.
Mark H StolerDepartment of Pathology, University of Virginia School of Medicine, Charlottesville, Virginia.
Nicholas R TemanDepartment of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia.
Victor E LaubachDepartment of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia.
Irving L KronDepartment of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia.
Mark E RoeserDepartment of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia. Electronic address: mr8be@virginia.edu.
University of Virginia · US

Funding

Cardiovascular Surgery Training ProgramT32HL007849 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI KRON, IRVING L., LAUBACH, VICTOR E · 1998 to 2025
$7.0M
In Vivo Lung Perfusion for the Surgical Treatment of Acute Respiratory Distress SyndromeR01HL142110 · NHLBI · UNIVERSITY OF VIRGINIA · PI KRON, IRVING L., LAUBACH, VICTOR E · 2018 to 2021
$2.3M
NHLBI NIH HHS R01 HL142110NHLBI NIH HHS T32 HL007849
6 · The paper itself

Abstract

introductionMainstays of current treatment for acute respiratory distress syndrome (ARDS) focus on supportive care and rely on intrinsic organ recovery. Animal models of ARDS are often limited by systemic injury. We hypothesize that superimposing gastric aspiration and ventilator-induced injury will induce a lung-specific injury model of severe ARDS. MATERIALS AND

methodsAdult swine (n = 8) were subject to a 12 h injury development period followed by 24 h of post-injury monitoring. Lung injury was induced with gastric secretions (3 cc/kg body weight/lung, pH 1-2) instilled to bilateral mainstem bronchi under direct bronchoscopic vision. Ventilator settings within the injury period contradicted baseline settings using high tidal volumes and low positive end-expiratory pressure. Baseline settings were restored following the injury period. Arterial oxygenation and lung compliance were monitored.

resultsAt 12 h, PaO

conclusionsTwelve hours of high tidal volume and low positive end-expiratory pressure in conjunction with low-pH gastric content instillation produces significant acute lung injury in swine. This large animal model may be useful for testing severe ARDS treatment strategies.

Indexed as

Interleukin-8Respiratory Distress SyndromeAnimalsInterleukin-6SwineTidal VolumeVentilators, MechanicalInterleukin-6Interleukin-8Acute respiratory distress syndromeAnimal modelLaboratory medicineLung functionOrgan dysfunction

Identifiers

PMID36030603
PMCPMC11227740
OpenAlexW4293679033

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.