Evidence map›Paper›PMID 36030576›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2022

Quiescence during burst suppression and postictal generalized EEG suppression are distinct patterns of activity.

MohammadMehdi Kafashan, L Brian Hickman, Alyssa K Labonte, Emma R Huels, Hannah Maybrier, Christian S Guay, Subha Subramanian, Nuri B Farber, ShiNung Ching, R Edward Hogan and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Targeting Slow Wave Sleep Deficiency in Late-Life Depression: A Case Series With Propofol.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

MohammadMehdi KafashanDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
L Brian HickmanDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Department of Neurology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.
Alyssa K LabonteDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Neuroscience Graduate Program, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Emma R HuelsNeuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA; Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Hannah MaybrierPsychological & Brain Sciences Department, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Christian S GuayDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Picower Institute for Learning & Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Subha SubramanianDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Nuri B FarberDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
ShiNung ChingDepartment of Electrical & Systems Engineering, Washington University in St. Louis, St. Louis, MO, USA; Division of Biology and Biomedical Sciences, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
R Edward HoganDepartment of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Max B KelzDepartment of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Michael S AvidanDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
George A MashourDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Ben J A PalancaDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Department of Electrical & Systems Engineering, Washington University in St. Louis, St. Louis, MO, USA; Division of Biology and Biomedical Sciences, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA. Electronic address: palancab@wustl.edu.
Washington University in St. Louis · USUniversity of Michigan–Ann Arbor · USUniversity of Pennsylvania · US

Funding

Washington University Institute of Clinical and Translational Sciences (TL1)TL1TR002344 · NCATS · WASHINGTON UNIVERSITY · PI Jay F. Piccirillo · 2017 to 2026
$8.5M
Early Stage Training in the NeurosciencesT32NS076401 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Carol Fuzeti Elias, LESLIE S. SATIN · 2011 to 2026
$3.1M
Disruptions of Brain Networks and Sleep by Electroconvulsive TherapyK01MH128663 · NIMH · WASHINGTON UNIVERSITY · PI MohammadMehdi Kafashan · 2022 to 2026
$792k
NCATS NIH HHS TL1 TR002344NIMH NIH HHS K01 MH128663NINDS NIH HHS T32 NS076401
6 · The paper itself

Abstract

objectivePeriods of low-amplitude electroencephalographic (EEG) signal (quiescence) are present during both anesthetic-induced burst suppression (BS) and postictal generalized electroencephalographic suppression (PGES). PGES following generalized seizures induced by electroconvulsive therapy (ECT) has been previously linked to antidepressant response. The commonality of quiescence during both BS and PGES motivated trials to recapitulate the antidepressant effects of ECT using high doses of anesthetics. However, there have been no direct electrographic comparisons of these quiescent periods to address whether these are distinct entities.

methodsWe compared periods of EEG quiescence recorded from two human studies: BS induced in 29 healthy adult volunteers by isoflurane general anesthesia and PGES in 11 patients undergoing right unilateral ECT for treatment-resistant depression. An automated algorithm allowed detection of EEG quiescence based on a 10-microvolt amplitude threshold. Spatial, spectral, and temporal analyses compared quiescent epochs during BS and PGES.

resultsThe median (interquartile range) voltage for quiescent periods during PGES was greater than during BS (1.81 (0.22) microvolts vs 1.22 (0.33) microvolts, p < 0.001). Relative power was greater for quiescence during PGES than BS for the 1-4 Hz delta band (p < 0.001), at the expense of power in the theta (4-8 Hz, p < 0.001), beta (13-30 Hz, p = 0.04) and gamma (30-70 Hz, p = 0.006) frequency bands. Topographic analyses revealed that amplitude across the scalp was consistently higher for quiescent periods during PGES than BS, whose voltage was within the noise floor.

conclusionsQuiescent epochs during PGES and BS have distinct patterns of EEG signals across voltage, frequency, and spatial domains. SIGNIFICANCE: Quiescent epochs during PGES and BS, important neurophysiological markers for clinical outcomes, are shown to have distinct voltage and frequency characteristics.

Indexed as

Electroconvulsive TherapyIsofluraneAdultAlgorithmsElectroencephalographyHumansSeizuresIsofluraneAnesthesiaBurst suppressionElectroconvulsive therapyElectroencephalographyMajor depressive disorderPostictal generalized electroencephalographic suppressionSeizures

Identifiers

PMID36030576
PMCPMC10287541
OpenAlexW4288905819

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.