Evidence map›Paper›PMID 36030499›Full record

ArticleClinical and translational medicine2022

IL-34 deficiency impairs FOXP3

Antoine Freuchet, Apolline Salama, Séverine Bézie, Laurent Tesson, Séverine Rémy, Romain Humeau, Hadrien Règue, Céline Sérazin, Léa Flippe, Pärt Peterson and 10 more

Open access · goldAbstract read
In one paragraph

Article in Clinical and translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. CRISPR-Cas9 applications in T cells and adoptive T cell therapies.Cellular & molecular biology letters · 2024
    Review
  6. Review
  7. T Cell Subsets and Immune Homeostasis.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  8. Genetic and Immunohistochemistry Tools to Visualize Rat Macrophages In Situ.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  9. Review
  10. Article
  11. IL-34 deficiency impairs FOXP3Clinical and translational medicine · 2022
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 4 countries.

Antoine FreuchetNantes Université, CHU Nantes, CNRS, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN5, Nantes, F-44000, France.
Apolline SalamaNantes Université, CHU Nantes, CNRS, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN5, Nantes, F-44000, France.
Séverine BézieNantes Université, CHU Nantes, CNRS, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN5, Nantes, F-44000, France.
Laurent TessonNantes Université, CHU Nantes, CNRS, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN5, Nantes, F-44000, France.
Séverine RémyNantes Université, CHU Nantes, CNRS, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN5, Nantes, F-44000, France.
Romain HumeauNantes Université, CHU Nantes, CNRS, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN5, Nantes, F-44000, France.
Hadrien RègueNantes Université, CHU Nantes, CNRS, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN5, Nantes, F-44000, France.
Céline SérazinNantes Université, CHU Nantes, CNRS, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN5, Nantes, F-44000, France.
Léa FlippeNantes Université, CHU Nantes, CNRS, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN5, Nantes, F-44000, France.
Pärt PetersonInstitute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Nadège VimondNantes Université, CHU Nantes, CNRS, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN5, Nantes, F-44000, France.
Claire UsalNantes Université, CHU Nantes, CNRS, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN5, Nantes, F-44000, France.
Séverine MénoretNantes Université, CHU Nantes, CNRS, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN5, Nantes, F-44000, France.
Jean-Marie HeslanNantes Université, CHU Nantes, CNRS, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN5, Nantes, F-44000, France.
Franck DuteilleChirurgie Plastique Reconstructrice et Esthétique, CHU Nantes, Nantes, France.
Frédéric BlanchardINSERM UMR1238, Bone Sarcoma and remodeling of calcified tissues, Nantes University, Nantes, France.
Magali GiralNantes Université, CHU Nantes, CNRS, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN5, Nantes, F-44000, France.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Ignacio AnegonNantes Université, CHU Nantes, CNRS, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN5, Nantes, F-44000, France.
Carole GuillonneauNantes Université, CHU Nantes, CNRS, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, ITUN5, Nantes, F-44000, France.ORCID 0000-0002-7195-0631
Centre National de la Recherche Scientifique · FRCentre de Chirurgie Plastique · CHInserm · FRUniversity of Tartu · EEWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmune homeostasis requires fully functional Tregs with a stable phenotype to control autoimmunity. Although IL-34 is a cytokine first described as mainly involved in monocyte cell survival and differentiation, we recently described its expression by CD8

methodsWe generated Il34

resultsHere we report that the absence of expression of IL-34 in Il34

conclusionAltogether, our data emphasize on the crucial necessity of IL-34 for immune homeostasis and for CD4 HIGHLIGHTS: -Absence of expression of IL-34 in Il34

Indexed as

ColitisGraft vs Host DiseaseInterleukinsT-Lymphocytes, RegulatoryAnimalsForkhead Transcription FactorsHomeostasisHumansImmune ToleranceMiceRatsForkhead Transcription FactorsFOXP3 protein, humanFoxp3 protein, mouseFoxp3 protein, ratIL34 protein, humanInterleukinsautoimmunityCRISPR/Cas9Foxp3IL-34immunotherapyknockoutrattoleranceTreg

Identifiers

PMID36030499
PMCPMC9420423
OpenAlexW4293408765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.