Long-term evolutionary adaptation of SIVcpz toward HIV-1 using a humanized mouse model.
Kimberly Schmitt, James Curlin, Leila Remling-Mulder, Jared Morrison, Ryan Moriarty, Kelly Goff, Mark Stenglein, Shelby O'Connor, Preston Marx, Ramesh Akkina
Article in Journal of medical primatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors.
Kimberly SchmittDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.ORCID 0000-0002-8445-3570
James CurlinDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.ORCID 0000-0002-9944-7173
Leila Remling-MulderDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Jared MorrisonDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Ryan MoriartyUniversity of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Kelly GoffTulane National Primate Research Center, Covington, Louisiana, USA.
Mark StengleinDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Shelby O'ConnorUniversity of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Preston MarxTulane National Primate Research Center, Covington, Louisiana, USA.
Ramesh AkkinaDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Funding
WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Modeling the molecular evolution of SIV to HIV using humanized miceR01AI123234 · NIAID · COLORADO STATE UNIVERSITY · PI AKKINA, RAMESH · 2016 to 2020
$2.4M
Training Program for Antiretroviral Discovery, Evaluation and Application Research (ADEAR)T32AI150547 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Joshua Adam Barocas, Kristine Mace Erlandson · 2020 to 2026
Critical genetic adaptations needed for SIV chimpanzee to evolve into HIV-1 are not well understood. Using humanized mice, we mimicked the evolution of SIVcpzLB715 into HIV-1 Group M over the course of four generations. Higher initial viral load, increased CD4
Indexed as
HIV-1Simian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusAnimalsDisease Models, AnimalEvolution, MolecularMicePan troglodytesViral LoadHIV-1 viral evolutionmodeling SIV evolution using humanized miceSIVcpz evolution into HIV-1SIV cross-species transmissionviral evolution in humanized mice
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Long-term evolutionary adaptation of SIVcpz toward HIV-1 using a humanized mouse model. · full record | OpenQuestion