ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2022
Sex-related differences in violence exposure, neural reactivity to threat, and mental health.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- The developments and emerging trends of Autonomic Nervous System Research in Arrhythmia: a bibliometric study from 2004 to 2024.Frontiers in neuroscience · 2025Pooled it
- The association between psychotic-like experiences and violent behavior in adolescents: a cross-lagged longitudinal study.European child & adolescent psychiatry · 2025Article
- Sex differences in response to violence: role of salience network expansion and connectivity on depression.Translational psychiatry · 2025Article
- Genetic risk predicts adolescent mood pathology via sexual differentiation of brain function and physiological aging.Nature communications · 2025Article
- Sex Differences in the Neurobiology of Fear and Anxiety.Current topics in behavioral neurosciences · 2025Review
- Workplace violence and its strong association with depression among Brazilian workers: insights from a national survey.Frontiers in psychiatry · 2025Article
- The prevalence and profiles of adverse childhood experiences and their associations with adult mental health outcomes in China: a cross-sectional study.The Lancet regional health. Western Pacific · 2024Article
- Sex-dependent differences in vulnerability to early risk factors for posttraumatic stress disorder: results from the AURORA study.Psychological medicine · 2024Article
- Sex Differences in Response Inhibition-Related Neural Predictors of Posttraumatic Stress Disorder in Civilians With Recent Trauma.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Impact of handgun ownership and biological sex on startle reactivity to predictable and unpredictable threats.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2024Article
- Sex Differences in the Effects of Cognitive Reappraisal Training on Conditioned Fear Responses.International journal of environmental research and public health · 2022Article
- Mitigating the impact of adolescence isolation on the development of social anxiety: A potential role for oxytocin.Frontiers in behavioral neuroscience · 2022Review
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
Abstract
The prefrontal cortex (PFC), hippocampus, and amygdala play an important role in emotional health. However, adverse life events (e.g., violence exposure) affect the function of these brain regions, which may lead to disorders such as depression and anxiety. Depression and anxiety disproportionately affect women compared to men, and this disparity may reflect sex differences in the neural processes that underlie emotion expression and regulation. The present study investigated sex differences in the relationship between violence exposure and the neural processes that underlie emotion regulation. In the present study, 200 participants completed a Pavlovian fear conditioning procedure in which cued and non-cued threats (i.e., unconditioned stimuli) were presented during functional magnetic resonance imaging. Violence exposure was previously assessed at four separate time points when participants were 11-19 years of age. Significant threat type (cued versus non-cued) × sex and sex × violence exposure interactions were observed. Specifically, women and men differed in amygdala and parahippocampal gyrus reactivity to cued versus non-cued threat. Further, dorsolateral PFC (dlPFC) and inferior parietal lobule (IPL) reactivity to threat varied positively with violence exposure among women, but not men. Similarly, threat-elicited skin conductance responses varied positively with violence exposure among women. Finally, women reported greater depression and anxiety symptoms than men. These findings suggest that sex differences in threat-related brain and psychophysiological activity may have implications for mental health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.