ReviewCritical care (London, England)2022
Acute kidney injury-associated delirium: a review of clinical and pathophysiological mechanisms.
Review in Critical care (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Acute Kidney Injury and Risk of Adverse Neurocognitive Outcomes: A Systematic Review and Meta-Analysis.Neurology · 2026Pooled it
- Five-decade prevalence of delirium in pneumonia, risk factors and associated mortality: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Association of acute kidney injury with the risk of cognitive impairment or dementia: a systematic review and meta-analysis.Renal failure · 2023Pooled it
- Overtime work of anesthesiologists is associated with increased delirium in older patients admitted to intensive care unit after noncardiac surgery: a secondary analysis.BMC anesthesiology · 2024Trial
- Impact of diabetic kidney disease on perioperative outcomes after lumbar spinal fusion: a propensity score analysis of the Nationwide Inpatient Sample.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Pre-existing anxiety and mood disorders and multisystem outcomes in young adults with chronic kidney disease.Clinical kidney journal · 2026Article
- Prediction of delirium in trauma patients using interpretable machine learning.Scientific reports · 2026Article
- Article
- Association between hemoglobin glycation index and delirium after gastric surgery: Based upon the MIMIC-IV.Medicine · 2026Article
- Propofol Use and Delirium in Patients Aged 80 Years and Over: A Retrospective Cohort Study of 9850 ICU Admissions.Drugs & aging · 2026Article
- Explainable machine learning for predicting mechanical ventilation in Alzheimer's patients with pneumonia: a SHAP-guided XGBoost nomogram based on MIMIC-IV.Scientific reports · 2026Article
- Incidence, predictors and outcomes of delirium in acute aortic syndrome.Journal of cardiothoracic surgery · 2026Article
- Research advances on acute kidney injury and brain dysfunction.Frontiers in nephrology · 2026Review
- Initial serum chloride is associated with all-cause mortality in critically ill patients with acute kidney injury.Renal failure · 2025Article
- Describing patterns of delirium in alcohol withdrawal and in non-alcohol withdrawal: An observational study in a tertiary care rural hospital.Indian journal of psychiatry · 2025Article
- Acute kidney injury and postoperative delirium.Journal of biomedical research · 2025Article
- The Prevalence, Risk Factors, and Short-Term Health Outcomes of Delirium in Patients Admitted to a Nephrology Ward in Eastern Europe: An Observational Prospective Cohort Study.Journal of clinical medicine · 2025Article
- Association between acute kidney injury, delirium and outcomes in patients with critical illness: a protocol for a systematic review.BMJ open · 2025Article
- Predictors of Post-Intensive Care Syndrome in ICU Survivors After Discharge: An Observational Study.Journal of clinical medicine · 2025Article
- Interpretable machine learning model for predicting delirium in patients with sepsis: a study based on the MIMIC data.BMC infectious diseases · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury is a known clinical risk factor for delirium, an acute cognitive dysfunction that is commonly encountered in the critically ill population. In this comprehensive review of clinical and basic research studies, we detail the epidemiology, clinical implications, pathogenesis, and management strategies of patients with acute kidney injury-associated delirium. Specifically addressed are the pathological roles of endogenous toxin or drug accumulation, acute kidney injury-mediated neuroinflammation, and acute kidney injury-associated volume overload as discrete potential biological mechanisms of the condition. The optimization of clinical contributors and normalization of renal function are reviewed as pragmatic management strategies in addition to potential and emerging therapeutic approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.