ArticleBiomaterials2022
Patch grafting of organoids of stem/progenitors into solid organs can correct genetic-based disease states.
Open access · hybridAbstract read
In one paragraph
Article in Biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Artificial Intelligence-Powered Histopathology in Stem Cell Research: Bridging Morphology, Function, and Omics.Current issues in molecular biology · 2026Review
- Progress and challenges in the development of advanced pancreatic cancer organoids.Journal of experimental & clinical cancer research : CR · 2026Review
- Conversion of Transplanted Mature Hepatocytes into AfpAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Single-cell sequencing and organoids: applications in organ development and disease.Molecular biomedicine · 2025Review
- Organoids in Genetic Disorders: from Disease Modeling to Translational Applications.Stem cell reviews and reports · 2025Review
- Bioprinted Organoids: An Innovative Engine in Biomedicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Biomedical applications of organoids in genetic diseases.Medical review (2021) · 2025Review
- Hormonally and chemically defined expansion conditions for organoids of biliary tree Stem Cells.Bioactive materials · 2024Article
- [Progress and application of liver organoids in the study of liver cancer].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023Article
- A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans.NPJ Regenerative medicine · 2023Article
- Liver cell therapies: cellular sources and grafting strategies.Frontiers of medicine · 2023Review
- A novel approach for hepatocyte transplantation at the liver surface.Cell transplantationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 8 institutions in 4 countries.
Wencheng ZhangDepartment of Cell Biology and Physiology, UNC School of Medicine, Chapel Hill, NC 27599, USA; Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200123, China; Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai, 200120, China; Shanghai Engineering Research Center of Stem Cells Translational Medicine, Shanghai, 200335, China. Electronic address: wencheng.v.zhang@outlook.com.
Eliane WauthierDepartment of Cell Biology and Physiology, UNC School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: elwauthier@gmail.com.
Giacomo LanzoniDiabetes Research Institute, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136, USA. Electronic address: giacomo.lanzoni@gmail.com.
Homayoun HaniDepartment of Cell Biology and Physiology, UNC School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: h.hani@gmail.com.
Xianwen YiDepartment of Surgery, UNC School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: xianwen_yi@med.unc.edu.
Diletta OveriAnatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Roma RM, Italy. Electronic address: diletta.overi@uniroma1.it.
Lei ShiDepartment of Cell Biology and Physiology, UNC School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: 302shilei@gmail.com.
Sean SimpsonDepartment of Molecular Biomedical Sciences, North Carolina State College of Veterinary Medicine, Raleigh, NC 27606, USA; The Comparative Medicine Institute, North Carolina State College of Veterinary Medicine, Raleigh, NC 27606, USA; Department of Comparative Veterinary Anatomy, North Carolina State College of Veterinary Medicine, Raleigh, NC 27606, USA. Electronic address: seangsimpson.ss@gmail.com.
Amanda AllenDepartment of Cell Biology and Physiology, UNC School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: volare266@gmail.com.
Carolyn SuittCenter on Gastrointestinal Disease Biology (CGIBD) Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: carolyn_suitt@med.unc.edu.
Jennifer Ashley EzzellDepartment of Cell Biology and Physiology, UNC School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: j.ezzell@email.unc.edu.
Domenico AlvaroCenter on Gastrointestinal Disease Biology (CGIBD) Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: domenico.alvaro@uniroma.it.
Vincenzo CardinaleDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Roma RM, Italy. Electronic address: v.cardinale80@gmail.com.
Eugenio GaudioAnatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Roma RM, Italy. Electronic address: eugenio.gaudio@uniroma.it.
Guido CarpinoTranslational and Precision Medicine, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Roma RM, Italy. Electronic address: guido.carpino@uniroma.it.
Glenn PrestwichDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, 00135, Italy. Electronic address: Glenn.Prestwich@pharm.utah.edu.
Juan Dominguez-BendalaDiabetes Research Institute, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136, USA. Electronic address: jDominguez2@med.miami.edu.
David GerberDepartment of Surgery, UNC School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: David_Gerber@med.unc.edu.
Kyle MathewsDepartment of Clinical Sciences, North Carolina State College of Veterinary Medicine, Raleigh, NC 27606, USA. Electronic address: kmathews@ncsu.edu.
Jorge PiedrahitaDepartment of Molecular Biomedical Sciences, North Carolina State College of Veterinary Medicine, Raleigh, NC 27606, USA; The Comparative Medicine Institute, North Carolina State College of Veterinary Medicine, Raleigh, NC 27606, USA; Department of Comparative Veterinary Anatomy, North Carolina State College of Veterinary Medicine, Raleigh, NC 27606, USA. Electronic address: japiedra@ncsu.edu.
Christopher AdinDepartment of Clinical Sciences, North Carolina State College of Veterinary Medicine, Raleigh, NC 27606, USA. Electronic address: adinc@ufl.edu.
Praveen SethupathyDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: pr46@cornell.edu.
Zhiying HeInstitute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200123, China; Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai, 200120, China; Shanghai Engineering Research Center of Stem Cells Translational Medicine, Shanghai, 200335, China. Electronic address: zyhe@tongji.edu.cn.
Lola M ReidDepartment of Cell Biology and Physiology, UNC School of Medicine, Chapel Hill, NC 27599, USA; Cornell University College of Veterinary Medicine, T7 006D Veterinary Research Tower, Box 17, Ithaca, NY 14853, USA. Electronic address: stemcell@med.unc.edu.
University of North Carolina Health Care · USNorth Carolina State University · USSapienza University of Rome · ITUniversity of Miami · USUniversity of North Carolina at Chapel Hill · USCornell University · USForo Italico University of Rome · ITShanghai East Hospital · CN
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5MPILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1985 to 2026
$30.5MINTERACTIVE GRAPHICS FOR MOLECULAR STUDIES &MICROSCOPYP41EB002025 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUPERFINE, RICHARD · 2003 to 2019
$16.9MTransgenesis and XenotransplantationR01HL051587 · NHLBI · TEXAS A&M UNIVERSITY SYSTEM · PI PIEDRAHITA, JORGE A · 1994 to 2013
$3.2MNCI NIH HHS P30 CA016086NHLBI NIH HHS R01 HL051587NIBIB NIH HHS P41 EB002025NIDDK NIH HHS P30 DK034987
Abstract
Patch grafting, a novel strategy for transplantation of stem/progenitor organoids into porcine livers, has been found successful also for organoid transplantation into other normal or diseased solid organs in pigs and mice. Each organoid contained ∼100 cells comprised of biliary tree stem cells (BTSCs), co-hepato/pancreatic stem/progenitors, and partnered with early lineage stage mesenchymal cells (ELSMCs), angioblasts and precursors to endothelia and stellate cells. Patch grafting enabled transplantation into livers or pancreases of ≥10
Indexed as
Biliary TractOrganoidsAnimalsLiverMicePancreasStem CellsSwineBiliary treeCell therapiesDiabetesLiverOrganoidsPancreasPatch graftingStem/progenitorsTyrosinemia
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.