Evidence map›Paper›PMID 36029878›Full record

ArticleJournal of affective disorders2022

What does "staying well" after depression mean? Chronic low grade symptomatology after treatment for depression is common.

Marlene V Strege, John A Richey, Greg J Siegle

Open access · greenAbstract read
In one paragraph

Article in Journal of affective disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Marlene V StregeUniversity of Pittsburgh, Department of Psychiatry, United States of America. Electronic address: stregem@upmc.edu.
John A RicheyVirginia Polytechnic Institute and State University, Department of Psychology, United States of America.
Greg J SiegleUniversity of Pittsburgh, Department of Psychiatry, United States of America.
University of Pittsburgh · USVirginia Tech · US

Funding

CLINICAL RESEARCH TRAINING FOR PSYCHOLOGISTST32MH018269 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MICHELE D LEVINE · 1986 to 2026
$6.3M
Functional Neuroanatomy of Recovery from DepressionR01MH074807 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SIEGLE, GREG J · 2006 to 2010
$1.9M
NIMH NIH HHS R01 MH074807NIMH NIH HHS T32 MH018269
6 · The paper itself

Abstract

backgroundPersistent low grade depression symptoms are common and impairing in major depressive disorder (MDD) yet rarely reported in treatment follow-up studies (Judd et al., 1998a; Kennedy et al., 2004), suggesting that extant sustained remission rates may not reflect this important clinical feature. Furthermore, no long-term MDD treatment follow-up study has reported on quality of life ratings across functioning levels and years throughout the follow-up period, thus the severity, breadth, and persistence of functional impairment remain unclear. Accordingly, the current study evaluated the course of MDD with consideration of low grade depressive symptomatology and holistic features (e.g., quality of life).

methodsWe report long-term (9-14 years) follow-up data from individuals with MDD (N = 37) who underwent either Cognitive Therapy (CBT) or a course of selective serotonin reuptake inhibitor (SSRI) treatment. Patients provided retrospective reports of depression symptoms and quality of life in the years following treatment.

resultsChronic depression symptoms (most often mild in severity) and decreased quality of life in multiple domains are frequent and suggest poorer sustained remission rates than previously observed in the literature. LIMITATIONS: Study limitations include small sample size recruited via convenience sampling methods.

conclusionsFindings support a conceptualization of depression recovery that entails persistent symptoms and vulnerabilities. Clinical recommendations are provided for discussing these features of depression recovery with patients.

Indexed as

Major Depressive DisorderSelective Serotonin Reuptake InhibitorsDepressionFollow-Up StudiesHumansQuality of LifeRetrospective StudiesSelective Serotonin Reuptake InhibitorsCognitive Behavior TherapyDepressionPharmacotherapyQuality of lifeTreatment

Identifiers

PMID36029878
PMCPMC10012845
OpenAlexW4292940381

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.