Evidence map›Paper›PMID 36029484›Full record

SynthesisReviews in medical virology2022

Prognostic value of novel serum biomarkers, including C-reactive protein to albumin ratio and fibrinogen to albumin ratio, in COVID-19 disease: A meta-analysis.

Sawai Singh Rathore, Sharvi Oberoi, Kinza Iqbal, Keshav Bhattar, Guadalupe Abigail Benítez-López, María Alejandra Nieto-Salazar, Felipe Velasquez-Botero, Guillermo Andrés Moreno Cortes, Jonathan Hilliard, Chinelo Chioma Madekwe and 3 more

Open access · greenAbstract readMeta-AnalysisReview
In one paragraph

Synthesis in Reviews in medical virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

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  15. The Impact of Hypoalbuminemia on Inflammatory Markers, Serum Creatinine, Hemoglobin and Outcome in Critically ill Patients With COVID-19 Infection-Retrospective Observation Study.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2025
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  20. Kinetics of C-reactive protein during extracorporeal membrane oxygenation.The International journal of artificial organs · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 7 countries.

Sawai Singh RathoreDr. Sampurnanand Medical College, Jodhpur, Rajasthan, India.ORCID 0000-0003-1954-094X
Sharvi OberoiDr. D. Y. Patil Medical College, Hospital & Research Centre, Pimpri, Pune, India.
Kinza IqbalDepartment of Internal Medicine, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.
Keshav BhattarDr. Sampurnanand Medical College, Jodhpur, Rajasthan, India.ORCID 0000-0003-0580-0130
Guadalupe Abigail Benítez-LópezLarkin Community Hospital, Miami, Florida, USA.
María Alejandra Nieto-SalazarJuan N. Corpas University, Bogotá, Colombia.ORCID 0000-0003-0574-532X
Felipe Velasquez-BoteroLarkin Community Hospital, Miami, Florida, USA.ORCID 0000-0002-1353-0428
Guillermo Andrés Moreno CortesLarkin Community Hospital, Miami, Florida, USA.
Jonathan HilliardAll Saints University College of Medicine, Amos Vale, Saint Vincent and the Grenadines.
Chinelo Chioma MadekweVinnytsya National Medical University, Vinnytsya, Ukraine.
Chika Chizitelu MadekweVinnytsya National Medical University, Vinnytsya, Ukraine.ORCID 0000-0002-5943-1636
Thomas C FlowersAll Saints University College of Medicine, Amos Vale, Saint Vincent and the Grenadines.
Khalil KhalilDepartment of Emergency Medicine, The Queen Elizabeth Hospital, King's Lynn, UK.
Larkin Community Hospital · USAll India Institute of Medical Sciences Jodhpur · INNational Pirogov Memorial Medical University, Vinnytsya · UASalvageBlue (Saint Vincent and the Grenadines) · VCDow University of Health Sciences · PKDr. D. Y. Patil Medical College, Hospital and Research Centre · INFundación Universitaria Juan N. Corpas · COQueen Elizabeth Hospital King's Lynn NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With COVID-19 still hovering around and threatening the lives of many at-risk patients, an effective, quick, and inexpensive prognostic method is required. Few studies have shown fibrinogen to albumin ratio (FAR) and C-reactive protein to albumin ratio (CAR) to be promising as prognostic markers for COVID-19 disease. However, their implications remain unclear. This meta-analysis aimed to elucidate the prognostic role of FAR and CAR in COVID-19 disease. A systematic literature search was undertaken using PubMed and Embase till April 2022. Inverse variance standardised mean difference (SMD) was calculated to report the overall effect size using random effect models. The generic inverse variance random-effects method was used to pool the area under the curve (AUC) values. All statistical analyses were performed on Revman and MedCalc Software. A total of 23 studies were included. COVID-19 non-survivors had a higher CAR on admission compared with survivors (SMD = 1.79 [1.04, 2.55]; p < 0.00001; I

Indexed as

COVID-19C-Reactive ProteinBiomarkersFibrinogenHumansPrognosisBiomarkersC-Reactive ProteinFibrinogenCARCOVID-19C-reactive protein to albumin ratioFARfibrinogen to albumin ratioprognostic marker

Identifiers

PMID36029484
PMCPMC9538909
OpenAlexW4293335333

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.