Evidence map›Paper›PMID 36029409›Full record

ArticleAdvances in experimental medicine and biology2022

Post-translational Modifications in Brain Diseases: A Future for Biomarkers.

Licia C Silva-Costa, Bradley J Smith

Abstract read
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In one paragraph

Article in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Licia C Silva-CostaLaboratory of Neuroproteomics, Department of Cell and Tissue Biology, Institute of Biology, State University of Campinas, Campinas, São Paulo, Brazil.
Bradley J SmithLaboratory of Neuroproteomics, Department of Cell and Tissue Biology, Institute of Biology, State University of Campinas, Campinas, São Paulo, Brazil. a22brad22@gmail.com.
Universidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several omic fields have been used in the development of biomarker panels, most traditionally involving genetics and proteomics. The post-translational modification of proteins, however, is an important regulatory system of many biological processes, affecting a wide range of biochemical properties of proteins, including their binding, localization, activity, and stability. These modifications are not analyzed if not specifically searched for in proteomic workflows, making them an underrepresented source of important information in the field of biomarker research. Biomarkers can particularly benefit the diagnosis and prognosis of neurological and psychiatric diseases due to the difficulty of accessing tissue and distinguishing between multiple possible conditions. In this article, post-translational modifications in the context of brain disease are compiled, highlighting the potential that this data source holds for improving the field of medicine.

Indexed as

Brain DiseasesProteomicsBiomarkersHumansProtein Processing, Post-TranslationalProteinsBiomarkersProteinsMass spectrometryMultifactorial diseasePost-translational modificationProteomics

Identifiers

PMID36029409
OpenAlexW4293353559

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.