Evidence map›Paper›PMID 36029398›Full record

ArticleJournal of neuro-oncology2022

Is intracranial volume a risk factor for IDH-mutant low-grade glioma? A case-control study.

Lisa Millgård Sagberg, Even Hovig Fyllingen, Tor Ivar Hansen, Per Sveino Strand, Aril Løge Håvik, Terje Sundstrøm, Alba Corell, Asgeir Store Jakola, Øyvind Salvesen, Ole Solheim

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuro-oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Lisa Millgård Sagberg *Department of Neurosurgery, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. lisa.millgard.sagberg@ntnu.no.ORCID http://orcid.org/0000-0001-7149-3082
Even Hovig Fyllingen *Department of Radiology and Nuclear Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.ORCID http://orcid.org/0000-0003-0495-1914
Tor Ivar HansenDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Per Sveino StrandDepartment of Neurosurgery, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.ORCID http://orcid.org/0000-0001-9883-3796
Aril Løge HåvikDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0002-2481-5808
Terje SundstrømDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0002-6503-7141
Alba CorellDepartment of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-6329-2392
Asgeir Store JakolaDepartment of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-2860-9331
Øyvind SalvesenClinical Research Unit, Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Ole SolheimDepartment of Neurosurgery, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.ORCID http://orcid.org/0000-0002-5954-4817
Norwegian University of Science and Technology · NOSahlgrenska University Hospital · SEHaukeland University Hospital · NOMolde Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRisk of cancer has been associated with body or organ size in several studies. We sought to investigate the relationship between intracranial volume (ICV) (as a proxy for lifetime maximum brain size) and risk of IDH-mutant low-grade glioma.

methodsIn a multicenter case-control study based on population-based data, we included 154 patients with IDH-mutant WHO grade 2 glioma and 995 healthy controls. ICV in both groups was calculated from 3D MRI brain scans using an automated reverse brain mask method, and then compared using a binomial logistic regression model.

resultsWe found a non-linear association between ICV and risk of glioma with increasing risk above and below a threshold of 1394 ml (p < 0.001). After adjusting for ICV, sex was not a risk factor for glioma.

conclusionIntracranial volume may be a risk factor for IDH-mutant low-grade glioma, but the relationship seems to be non-linear with increased risk both above and below a threshold in intracranial volume.

Indexed as

Brain NeoplasmsGliomaCase-Control StudiesHumansIsocitrate DehydrogenaseMagnetic Resonance ImagingMutationRisk FactorsIsocitrate DehydrogenaseBrain neoplasmsHUNT studyLow-grade gliomaMagnetic resonance imagingRisk factors

Identifiers

PMID36029398
PMCPMC9622551
OpenAlexW4293315952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.