ArticleAnnals of surgical oncology2022
Preoperative Smoking Cessation and Prognosis After Curative Esophagectomy for Esophageal Cancer: A Cross-Sectional Study.
Article in Annals of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Smoking and Complications After Cancer Surgery: A Systematic Review and Meta-Analysis.JAMA network open · 2025Pooled it
- Effects of Postoperative Complications on Overall Survival Following Esophagectomy: A Meta-Analysis Using the Restricted Mean Survival Time Analysis.Thoracic cancer · 2025Pooled it
- Multimodal prehabilitation program for patients undergoing elective surgery for colorectal cancer: a scoping review.Frontiers in oncology · 2025Pooled it
- Review
- Association between preoperative heat-not-burn cigarette smoking and short-term outcomes after esophagectomy: a nationwide cohort study of 17,797 patients from the Japanese National Clinical Database.Esophagus : official journal of the Japan Esophageal Society · 2026Article
- Younger women with esophageal carcinoma exhibit improved prognosis after esophagectomy: a single-center, high-volume cohort study.BMC cancer · 2026Article
- Optimizing Perioperative Care in Esophageal Surgery: The EUropean PErioperative MEdical Networking (EUPEMEN) Collaborative for Esophagectomy.Diseases (Basel, Switzerland) · 2025Article
- Risk factors of poor long-term outcomes in elderly patients with esophageal squamous cell carcinoma after minimally invasive esophagectomy.Surgery today · 2025Article
- Association of operative time and approach on postoperative complications for esophagectomy.Surgery · 2024Article
- Specialist cancer hospital-based smoking cessation service provision in Ireland.Irish journal of medical science · 2024Article
- Measurement and optimization of perioperative risk among patients undergoing surgery for esophageal cancer.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2024Article
- Days of the week and 90-day mortality after esophagectomy: analysis of 33,980 patients from the National Clinical Database.Langenbeck's archives of surgery · 2024Article
- Relationship between the severity of emphysematous change in the lung and morbidity after esophagectomy for esophageal cancer: A retrospective study on a novel strategy for risk prediction.Thoracic cancer · 2024Article
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral cohort studies have reported that post-esophagectomy morbidities may worsen prognosis. Smoking cessation is an effective prophylactic measure for reducing post-esophagectomy morbidity; however, whether smoking cessation can contribute to the improvement of prognosis is unknown due to the absence of reliable databases covering the cessation period. This study aimed to elucidate whether sufficient preoperative smoking cessation can improve prognosis after esophageal cancer surgery by reducing post-esophagectomy morbidity.
methodsThis study included 544 consecutive patients who underwent curative McKeown and Ivor-Lewis esophagectomies for esophageal cancer between May 2011 and June 2021. Data on smoking status and cessation period were prospectively accumulated. Survival data were finally updated on 30 January 2022. Receiver operating characteristic curve analysis for the cut-off value of appropriate cessation period in reducing post-esophagectomy respiratory morbidity as well as analyses for the association of cessation period with short- and long-term outcomes were performed.
resultsPost-esophagectomy morbidity significantly diminished overall survival (OS) after esophagectomy (p = 0.0003). A short preoperative smoking cessation period of ≤ 2 months was associated with frequent post-esophagectomy morbidity of Clavien-Dindo classification ≥IIIb (p = 0.0059), pneumonia (p = 0.016), respiratory morbidity (p = 0.0057), and poor OS in clinical stages II and III (p = 0.0015). Moreover, it was an independent factor for poor OS (hazard ratio 1.85, 95% confidence interval 1.068-3.197; p = 0.028), along with body mass index <18.5 and R1 resection.
conclusionsSufficient preoperative smoking cessation > 2 months may be effective in improving not only short-term outcomes but also prognosis after esophagectomy for locally advanced esophageal cancer.
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