ArticlePhysiological reports2022
The relationship between esophageal acidity and symptom frequency in symptomatic nonerosive gastroesophageal reflux disease.
Article in Physiological reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 9 citations in OpenAlex.
- Exploratory analyses of meal-induced heartburn identify distinct clinical phenotypes of gastroesophageal reflux disease.Physiological reports · 2025Trial
- Reassessing negative 24 h pH impedance tests for hidden gastroesophageal reflux disease using multi feature anomaly detection.NPJ digital medicine · 2026Article
- The relationship between esophageal acidity and symptom frequency in symptomatic nonerosive gastroesophageal reflux disease.Physiological reports · 2022Article
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1 author at 1 institution in 1 country.
Funding
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Abstract
The present paper examines the extent to which novel measures of esophageal acid exposure can elucidate possible relationships between symptom perception and esophageal acidity in subjects with nonerosive gastroesophageal reflux disease. Recordings of esophageal pH and symptom occurrence from 20 subjects with nonerosive gastroesophageal reflux disease were analyzed. Interval esophageal acid exposure was calculated in two different ways for the interval that preceded each symptom in each subject. Interval esophageal acidity was calculated as the time-weighted acid concentration for the interval. Interval esophageal acid exposure time was calculated as the percentage of the total recording time that esophageal pH was less than pH 4 for the interval. There was a negative relationship between the probability of a symptom and interval esophageal acid exposure indicating the paradoxical finding that the lower the value of esophageal acid exposure, the higher the probability of a symptom. The time courses of symptoms and cumulative esophageal acidity resolved this paradox by indicating that esophageal acid exposure oscillates between longer periods of low esophageal acid exposure with a high number of symptoms reflecting high esophageal acid sensitivity, and shorter periods of high esophageal acid exposure with fewer symptoms reflecting low esophageal acid sensitivity. Thus, the present analyses show how novel measures of acidity can identify and also resolve a previously unrecognized paradoxical relationship between esophageal acid exposure and symptom frequency in subjects with nonerosive gastroesophageal reflux disease.
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