Association of Inherited Thrombophilia with Recurrent Pregnancy Loss in A Population of Lebanese Women: A Case Control Study.

Recurrent pregnancy loss (RPL) complication is a challenge of reproductive medicine due to its often unknown etiology.<br />A case-control study was carried out between June 2019 and April 2020 to examine the correlation between RPL<br />and inherited thrombophilia (IT), namely mutations in factor V Leiden (FVL G1691A), prothrombin (FII G20210A),<br />and methylenetetrahydrofolate reductase (MTHFR C677T). A total of 120 Lebanese women with RPL was studied<br />and compared, for the frequency of these mutations, to 100 healthy reproductive Lebanese women. The association<br />between the zygosity status of the three tested mutations, the existence of more than one prothrombotic single nucleotide<br />polymorphisms (SNPs), and the increased risk of RPL were examined using Chi-square or two-tailed fisher exact<br />test, and the student t test. The predictive factors of RPL were analyzed using a multiple logistic regression model.<br />P<0.05 was considered to be statistically significant. Our results showed statistically significant higher frequencies<br />of FVL G1691A and FII G20210A mutations among the cases with RPL compared to the control group. Thus, RPL is<br />associated with FVL G1691A and FII G20210A mutations. These mutations seem to increase the risk of RPL in the<br />Lebanese women. Therefore, we suggest thrombophilia screening and adequate genetic counseling for women with<br />RPL and at high-risk to plan for primary prevention, avoiding thromboembolic or obstetric accidents, and reducing<br />the associated morbidity and mortality among Lebanese women.