ArticleInternational journal of fertility & sterility2022
New Approaches to Define The Functional Competency of Human Sperm Subpopulations and Its Relationship to Semen Quality.
Article in International journal of fertility & sterility, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 5 citations in OpenAlex.
- Dairy bull sperm subpopulation behaviour in frozen-thawed semen across breed, temperature, and thawing time.Veterinarni medicina · 2026Article
- Human sperm as an in vitro toxicity model: a versatile tool for assessing the risk of environmental contaminants.Archives of toxicology · 2025Article
- Effect of in vitro exposure of first-line antiretrovirals on healthy human spermatozoa on kinematics and motility.International urology and nephrology · 2025Article
- Seminal plasma protein profiles based on molecular weight as biomarkers of sperm fertility in horned and polled Bali bulls.Veterinary world · 2025Article
- Chromatin condensation but not DNA integrity of pig sperm is greater in the sperm-rich fraction.Journal of animal science and biotechnology · 2023Article
- Origin, Migration, and Reproduction of Indigenous Domestic Animals with Special Reference to Their Sperm Quality.Animals : an open access journal from MDPI · 2022Review
- Progesterone, Myo-Inositol, Dopamine and Prolactin Present in Follicular Fluid Have Differential Effects on Sperm Motility Subpopulations.Life (Basel, Switzerland) · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed at comparing a comprehensive set of functional and structural sperm characteristics between sperm motility fractions and correlating results to the standard semen parameters. By grouping related variables, our objective was to establish the predictive power of semen parameters and whether they accurately reflect the functionality of sperm motility fractions or merely a small set of parameters within individual fractions.<br />Materials and Methods: In this non-invasive experimental study, donor semen samples (n=55) were separated via<br />double density gradient centrifugation, isolating a high (HM) and low motile (LM) sperm fraction. Fractions were evaluated for percentage vitality, chromatin integrity, mature spermatozoa, motility and kinematic parameters, hyperactivation, positive reactive oxygen species, intact mitochondrial membrane potential (MMP) and acrosome reaction.<br />Results: HM fractions had significantly (P<0.001) enhanced percentages of induced acrosome reaction (HM, 55.6 ±<br />14.3%, LM, 25.0 ± 16.5%), motility and kinematic parameters, hyperactivation, vitality (HM, 70.4 ± 9.7%, LM, 47.9<br />± 10.3%), mitochondrial membrane intactness (HM, 67.2 ± 10.4%, LM, 44.7 ± 15.0%) and mature spermatozoa (HM,<br />83.4 ± 10.0%, LM, 64.6 ± 8.2%) with intact chromatin (HM, 80.5 ± 8.1%, LM, 71.3 ± 8.0%). Various sperm morphology abnormalities correlated with LM fractions' grouped motility parameters (range, 0.46 to 0.51; range -0.4 to<br />-0.75), whereas combined semen traits of total motility, progressive motility, viscosity and mucus penetration (MPT) correlated with HM fractions' grouped motility parameters (range, 0.44 to 0.84).
conclusionCollectively, total and progressive motility, viscosity and MPT may represent a reliable grouping of semen parameters for predicting the quality of HM sperm fractions. Separating the same donor semen samples into two significantly diverse motility sperm fractions could be a potential model in mimicking the qualities of fertile and sub-fertile males' sperm populations and used for future research on the improvement of sperm subpopulations from males with different fertility statuses.
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