ArticleBJS open2022
Demographic trends in the incidence of malignant appendiceal tumours in England between 1995 and 2016: Population-based analysis.
Article in BJS open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Incidence rate and histology of appendiceal neoplasms in complicated versus uncomplicated appendicitis: A meta-analysis and systematic review.Langenbeck's archives of surgery · 2023Pooled it
- Surgical Extent and Long-term Survival in Appendiceal Adenocarcinoma: A Systematic Review and Meta-analysis.In vivo (Athens, Greece)Pooled it
- Are the long-term oncologic outcomes different between appendiceal cancer and right-sided colon cancer? An exact matching analysis of a 10-year institutional cohort.Annals of surgical treatment and research · 2026Article
- Epidemiology and histopathological spectrum of appendiceal pathologies in 40.286 adults: a multicenter study from Turkey (2017-2025).European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Appendiceal Collision Tumors: An Institutional Case Series and Systematic Review of the Histologic Spectrum, Clinical Outcomes, and Management Strategies.Diagnostics (Basel, Switzerland) · 2025Article
- Article
- Advanced Computational Modeling and Machine Learning for Risk Stratification, Treatment Optimization, and Prognostic Forecasting in Appendiceal Neoplasms.Healthcare (Basel, Switzerland) · 2025Article
- Dethroning of Neuroendocrine Tumor as an Orphan Disease: US Incidence, Prevalence, and Survival in the 21st Century.Cancers · 2025Article
- Clinicopathological Profile and Management of Appendiceal Neoplasm: An Observational Study.JNMA; journal of the Nepal Medical Association · 2025Observational
- Age-specific trends in colorectal, appendiceal, and anal tumour incidence by histological subtype in Australia from 1990 to 2020: a population-based time-series analysis.medRxiv : the preprint server for health sciences · 2025Article
- Incidence of Malignancy in Appendicectomy Specimens.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Article
- Sufficient Regional Lymph Node Examination for Staging Adenocarcinoma of the Appendix.Annals of surgical oncology · 2024Article
- Current Status of Treatment among Patients with Appendiceal Tumors-Old Challenges and New Solutions?Cancers · 2024Review
- Case report: A rare case of coexistence of low-grade appendiceal mucinous neoplasia and goblet cell adenocarcinoma in the appendix.Frontiers in oncology · 2024Article
- High Incidence of Appendiceal Neoplasms in the Elderly: A Critical Concern for Non-Surgical Treatment.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2023Article
- Neuroendocrine tumors of the appendix: a comprehensive review of the literature and case presentation.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieReview
- Survival outcomes used to validate version 9 of the American Joint Committee on Cancer staging system for appendiceal cancer.CA: a cancer journal for cliniciansReview
- Appendiceal Tumors: A Narrative Review.In vivo (Athens, Greece)Review
- Appendiceal Neuroendocrine Tumor: Clinicopathologic Characteristics of Six Cases and Review of the Literature.In vivo (Athens, Greece)Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
aimsRecent data suggest that the incidence of malignant appendiceal tumours is increasing. This study aimed to determine temporal trends in the incidence of malignant appendiceal tumours within England and a possible influence by demographic factors.
methodsAll incident cases of appendiceal tumours in patients aged 20 years and above were identified from the National Cancer Registration and Analysis Service database between 1995 and 2016 using ICD-9/10 codes. Cancers were categorized according to histology. Joinpoint regression analysis was used to investigate changes in age-standardized incidence rates by age, sex, histological subtype and index of multiple deprivation quintiles, based on socioeconomic domains (income, employment, education, health, crime, barriers to housing and services and living environment). Average annual per cent changes (AAPCs) were estimated by performing Monte-Carlo permutation analysis.
resultsA total of 7333 tumours were diagnosed and 7056 patients were analysed, comprising 3850 (54.6 per cent) neuroendocrine tumours (NETs), 1892 (26.8 per cent) mucinous adenocarcinomas and 1314 (18.6 per cent) adenocarcinoma (not otherwise specified). The overall incidence of appendiceal tumours increased from 0.3 per 100 000 to 1.6 per 100 000 over the study interval. Incidence rate increases of comparable magnitude were observed across all age groups, but the AAPC was highest among patients aged 20-29 years (15.6 per cent, 95 per cent c.i 12.7-18.6 per cent) and 30-39 years (14.2 per cent, 12.2-16.2 per cent) and lowest among those aged 70-79 years (6.8 per cent, 5.7-8.0 per cent). Similar incidence rate increases were reported across all socioeconomic deprivation quintiles and in both sexes. Analysis by grade of NET showed that grade 1 tumours accounted for 63 per cent between 2010 and 2013, compared with 2 per cent between 2000 and 2003.
conclusionsThe incidence rate of malignant appendiceal tumours has increased significantly since 1995 and is mainly attributed to an increase in NETs. The increased diagnosis of low-grade NETs may in part be due to changes in pathological classification systems.
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