Evidence map›Paper›PMID 36028826›Full record

ArticleRespiratory research2022

Utility of bile acids in large airway bronchial wash versus bronchoalveolar lavage as biomarkers of microaspiration in lung transplant recipients: a retrospective cohort study.

Chen Yang Kevin Zhang, Musawir Ahmed, Ella Huszti, Liran Levy, Sarah E Hunter, Kristen M Boonstra, Sajad Moshkelgosha, Andrew T Sage, Sassan Azad, Rasheed Ghany and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Observational
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Chen Yang Kevin ZhangToronto Lung Transplant Program, University Health Network, Toronto, Canada.
Musawir AhmedToronto Lung Transplant Program, University Health Network, Toronto, Canada.
Ella HusztiBiostatistics Research Unit, University Health Network, Toronto, Canada.
Liran LevyToronto Lung Transplant Program, University Health Network, Toronto, Canada.
Sarah E HunterToronto Lung Transplant Program, University Health Network, Toronto, Canada.
Kristen M BoonstraToronto Lung Transplant Program, University Health Network, Toronto, Canada.
Sajad MoshkelgoshaToronto Lung Transplant Program, University Health Network, Toronto, Canada.
Andrew T SageToronto Lung Transplant Program, University Health Network, Toronto, Canada.
Sassan AzadToronto Lung Transplant Program, University Health Network, Toronto, Canada.
Rasheed GhanyToronto Lung Transplant Program, University Health Network, Toronto, Canada.
Jonathan C YeungToronto Lung Transplant Program, University Health Network, Toronto, Canada.
Oscar M CrespinDivision of General Surgery, University Health Network, Toronto, Canada.
Lianne G SingerToronto Lung Transplant Program, University Health Network, Toronto, Canada.
Shaf KeshavjeeToronto Lung Transplant Program, University Health Network, Toronto, Canada.
Tereza MartinuToronto Lung Transplant Program, University Health Network, Toronto, Canada. tereza.martinu@uhn.ca.
University Health Network · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBronchoalveolar lavage (BAL) is a key tool in respiratory medicine for sampling the distal airways. BAL bile acids are putative biomarkers of pulmonary microaspiration, which is associated with poor outcomes after lung transplantation. Compared to BAL, large airway bronchial wash (LABW) samples the tracheobronchial space where bile acids may be measurable at more clinically relevant levels. We assessed whether LABW bile acids, compared to BAL bile acids, are more strongly associated with poor clinical outcomes in lung transplant recipients.

methodsConcurrently obtained BAL and LABW at 3 months post-transplant from a retrospective cohort of 61 lung transplant recipients were analyzed for taurocholic acid (TCA), glycocholic acid (GCA), and cholic acid by mass spectrometry and 10 inflammatory proteins by multiplex immunoassay. Associations between bile acids with inflammatory proteins and acute lung allograft dysfunction were assessed using Spearman correlation and logistic regression, respectively. Time to chronic lung allograft dysfunction and death were evaluated using multivariable Cox proportional hazards and Kaplan-Meier methods.

resultsMost bile acids and inflammatory proteins were higher in LABW than in BAL. LABW bile acids correlated with inflammatory proteins within and between sample type. LABW TCA and GCA were associated with acute lung allograft dysfunction (OR = 1.368; 95%CI = 1.036-1.806; P = 0.027, OR = 1.064; 95%CI = 1.009-1.122; P = 0.022, respectively). No bile acids were associated with chronic lung allograft dysfunction. Adjusted for risk factors, LABW TCA and GCA predicted death (HR = 1.513; 95%CI = 1.014-2.256; P = 0.042, HR = 1.597; 95%CI = 1.078-2.366; P = 0.020, respectively). Patients with LABW TCA in the highest tertile had worse survival compared to all others.

conclusionsLABW bile acids are more strongly associated than BAL bile acids with inflammation, acute lung allograft dysfunction, and death in lung transplant recipients. Collection of LABW may be useful in the evaluation of microaspiration in lung transplantation and other respiratory diseases.

Indexed as

Lung TransplantationTransplant RecipientsBile Acids and SaltsBiomarkersBronchoalveolar LavageBronchoalveolar Lavage FluidCohort StudiesHumansLungRetrospective StudiesBile Acids and SaltsBiomarkersBile acidsBiomarkersBronchoalveolar lavageLarge airway bronchial washLung transplantationMicroaspiration

Identifiers

PMID36028826
PMCPMC9419323
OpenAlexW4293678296

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.