Evidence map›Paper›PMID 36028757›Full record

Trial reportBone marrow transplantation2022

Reduced-toxicity myeloablative conditioning regimen using fludarabine and full doses of intravenous busulfan in pediatric patients not eligible for standard myeloablative conditioning regimens: Results of a multicenter prospective phase 2 trial.

Fanny Rialland, Audrey Grain, Myriam Labopin, Gerard Michel, Virginie Gandemer, Catherine Paillard, Cécile Pochon, Laurence Clement, Eolia Brissot, Charlotte Jubert and 5 more

Abstract readClinical Trial, Phase IIMulticenter Study
PubMed Publisher
In one paragraph

Trial report in Bone marrow transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 1 country.

Fanny RiallandCHU de Nantes, Nantes, France. fanny.rialland@chu-nantes.fr.ORCID 0000-0002-3136-6270
Audrey GrainCHU de Nantes, Nantes, France.
Myriam LabopinSorbonne University, Saint-Antoine Hospital, AP-HP, INSERM UMRs 938, Paris, France.ORCID 0000-0003-4514-4748
Gerard MichelDepartment of Pediatric Immunology, Hematology and Oncology, Timone Enfants Hospital and Aix-Marseille University, Marseille, France.ORCID 0000-0002-0018-5709
Virginie GandemerUniversity hospital of Rennes, University of Rennes1, Rennes, France.
Catherine PaillardDepartment of Paediatric Haematology and Oncology, Strasbourg University Hospital, Strasbourg, France.
Cécile PochonHôpital Brabois, Nancy, France.
Laurence ClementCHU Bordeaux, Bordeaux, France.
Eolia BrissotSorbonne University, Saint-Antoine Hospital, AP-HP, INSERM UMRs 938, Paris, France.
Charlotte JubertCHU Bordeaux, Bordeaux, France.
Anne SirventUniversity Hospital, Montpellier, France.
Pierre Simon RohrlichNice University Hospital, Nice, France.ORCID 0000-0001-8801-4164
Dominique PlantazUniversity Hospital of Grenoble, La Tronche, France.
Jean-Hugues DalleHôpital Robert Debré, GH APHP Nord - Université de Paris, Paris, France.
Mohamad MohtySorbonne University, Saint-Antoine Hospital, AP-HP, INSERM UMRs 938, Paris, France.ORCID 0000-0002-7264-808X
Inserm · FRCentre Hospitalier Universitaire de Bordeaux · FRCentre Hospitalier Universitaire de Nantes · FRAix-Marseille Université · FRCentre Hospitalier Régional et Universitaire de Nancy · FRCentre Hospitalier Universitaire de Grenoble · FRCentre Hospitalier Universitaire de Montpellier · FRCentre Hospitalier Universitaire de Nice · FRCentre Hospitalier Universitaire de Rennes · FRHôpitaux Universitaires de Strasbourg · FRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Data regarding the safety and efficacy of reduced-toxicity conditioning regimen (RTC) prior to allogeneic stem cell transplantation (allo-SCT) to treat hematological malignancies in pediatric patients are limited. This prospective multicenter, phase 2 trial investigated a RTC regimen based on the combination of intravenous busulfan (3.2 mg/kg/d x 4 days), fludarabine (30 mg/m

Indexed as

Hematopoietic Stem Cell TransplantationTransplantation ConditioningAdolescentBusulfanChildChild, PreschoolHumansProspective StudiesVidarabineYoung AdultBusulfanfludarabineVidarabine

Identifiers

PMID36028757
OpenAlexW4293109598

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.