ArticleClinical neuroradiology2023
Epidural Blood Patching in Spontaneous Intracranial Hypotension-Do we Really Seal the Leak?
Article in Clinical neuroradiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06711731 (The Freiburg Registry on SpontanEous IntercrAnial Hypotension), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Freiburg Registry on SpontanEous IntercrAnial Hypotension (SIH) & Post-duraL Puncture Headache (PDPH)
Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Continuous Epidural Infusion of Hydroxyethyl Starch for Spontaneous Intracranial Hypotension: A Retrospective Case Series.The American journal of case reports · 2026Article
- A technique to localize posteriorly located spinal dural leaks associated with spontaneous intracranial hypotension: Dorsal-decubitus dynamic CT myelography.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Article
- Manual Therapy-Associated Dural Tear Causing Intracranial Hypotension Treated with an Epidural Blood Patch: A Case Report.Journal of clinical medicine · 2026Article
- Modified Ultrafast Dynamic CT Myelography: Method, Outcomes, and Comparison With Noninvasive Imaging.Journal of clinical neurology (Seoul, Korea) · 2026Article
- Surgical management of ventral epidural cerebrospinal fluid leak: a scoping review and illustrative case.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
- Catheter-Guided Caudal Epidural Blood Patch for Refractory CSF Leak After Multiple Spine Surgeries: A Novel Case Report.Anesthesiology and pain medicine · 2025Article
- Occult spinal CSF leak: to patch or not to patch-a case-based update.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Review
- Continuous epidural saline infusion for spontaneous intracranial hypotension with cortical vein thrombosis: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Beyond the Headaches: Severe Dysphagia As the Dominant Symptom of Spontaneous Intracranial Hypotension.Cureus · 2025Article
- The impact of CSF venous fistula embolization on patient's quality of life, a longitudinal clinical-radiological exploration.The journal of headache and pain · 2025Article
- Safety, Sequelae, and Efficacy of Nerve Root Clipping in Patients With Spontaneous Spinal Cerebrospinal Fluid Leaks.Operative neurosurgery (Hagerstown, Md.) · 2025Article
- Assessing the effects of spontaneous intracranial hypotension on quality of life, work ability and disability.Wiener klinische Wochenschrift · 2025Article
- Through Both Lenses: A Dual Perspective on Illness.Journal of patient experience · 2025Article
- Spontaneous intracranial hypotension - Neurological symptoms, diagnosis, and outcome.European journal of neurology · 2025Article
- Minimally Invasive Approaches to Spinal Cerebrospinal Fluid Leak Repair: Current Strategies and a Novel Technique.Journal of personalized medicine · 2024Article
- Spinal dementia: Don't miss it, it's treatable.Neuroradiology · 2024Article
- Health-related quality of life, work ability and disability among individuals with persistent post-dural puncture headache.The journal of headache and pain · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEpidural blood patch (EBP) is a minimally invasive treatment for spontaneous intracranial hypotension (SIH). Follow-up after EBP primarily relies on clinical presentation and data demonstrating successful sealing of the underlying spinal cerebrospinal fluid (CSF) leak are lacking. Our aim was to evaluate the rate of successfully sealed spinal CSF leaks in SIH patients after non-targeted EBP.
methodsPatients with SIH and a confirmed spinal CSF leak who had been treated with non-targeted EBP were retrospectively analyzed. Primary outcome was persistence of CSF leak on spine MRI or intraoperatively. Secondary outcome was change in clinical symptoms after EBP.
resultsIn this study 51 SIH patients (mean age, 47 ± 13 years; 33/51, 65% female) treated with non-targeted EBP (mean, 1.3 EBPs per person; range, 1-4) were analyzed. Overall, 36/51 (71%) patients had a persistent spinal CSF leak after EBP on postinterventional imaging and/or intraoperatively. In a best-case scenario accounting for missing data, the success rate of sealing a spinal CSF leak with an EBP was 29%. Complete or substantial symptom improvement in the short term was reported in 45/51 (88%), and in the long term in 17/51 (33%) patients.
conclusionNon-targeted EBP is an effective symptomatic treatment providing short-term relief in a substantial number of SIH patients; however, successful sealing of the underlying spinal CSF leak by EBP is rare, which might explain the high rate of delayed symptom recurrence. The potentially irreversible and severe morbidity associated with long-standing intracranial hypotension supports permanent closure of the leak.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.