Evidence map›Paper›PMID 36028577›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2022

Quantitative PET imaging of the CD4 pool in nonhuman primates.

Insook Kim, Sharat Srinivasula, Paula DeGrange, Brad Long, Hyukjin Jang, Jorge A Carrasquillo, H Clifford Lane, Michele Di Mascio

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Advances and challenges in immunoPET methodology.Frontiers in nuclear medicine · 2024
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Insook Kim *AIDS Imaging Research Section, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA.
Sharat Srinivasula *AIDS Imaging Research Section, Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA.
Paula DeGrangeAIDS Imaging Research Section, Integrated Research Facility, NIAID, NIH, Frederick, MD, 21702, USA.
Brad LongAIDS Imaging Research Section, Integrated Research Facility, NIAID, NIH, Frederick, MD, 21702, USA.
Hyukjin JangAIDS Imaging Research Section, Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA.
Jorge A CarrasquilloMolecular Imaging and Therapy Service, Radiology Department, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
H Clifford LaneLaboratory of Immunoregulation, Division of Intramural Research, NIAID, NIH, Bethesda, MD, 20892, USA.
Michele Di MascioAIDS Imaging Research Section, Division of Clinical Research, NIAID, NIH, Bethesda, MD, 20892, USA. mdimascio@niaid.nih.gov.ORCID http://orcid.org/0000-0001-6609-9689
Frederick National Laboratory for Cancer Research · USOffice of AIDS Research · USMemorial Sloan Kettering Cancer Center · USNational Institute of Allergy and Infectious Diseases · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

purposePrevious SPECT and PET semi-quantitative in vivo imaging studies in monkeys have demonstrated specific uptake of radiolabeled rhesus recombinant anti-CD4 monoclonal antibody fragment CD4R1-F(ab΄)

methodsThe biodistributions of [

resultsThe biodistributions of [

conclusionThe majority of specific binding to CD4 + tissue was localized to LNs and spleen with minimal uptake in the gut. Binding potential derived from fully quantitative studies revealed that the contribution of the gut is lower than the spleen's contribution to the total body CD4 pool.

Indexed as

Positron-Emission TomographyZirconiumAnimalsKineticsMacaca mulattaZirconiumBinding potentialCD4R1 antibodyGut CD4 poolIbalizumabImmuno-PETSIV-infected

Identifiers

PMID36028577
PMCPMC9668939
OpenAlexW4293795493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.