ArticleScientific reports2022
3D transcranial ultrasound localization microscopy for discrimination between ischemic and hemorrhagic stroke in early phase.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Ultrasound localisation microscopy tracks testicular microvascular adaptations to endocrine function in male infertility.EBioMedicine · 2026Article
- Laser Ultrasound Super-Resolution Imaging for Multi-Parametric Non-Invasive Volumetric Characterization of Brain Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Multi-lens ultrasound arrays enable large scale three-dimensional micro-vascularization characterization over whole organs.Nature communications · 2025Article
- Imaging the brain by traversing the skull with light and sound.Nature biomedical engineering · 2025Review
- Ultrasound matrix imaging for 3D transcranial in vivo localization microscopy.Science advances · 2025Article
- Advancements in Three-Dimensional Super-Resolution Ultrasound Imaging: A Narrative Review.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Review
- Microvascular Ultrasound Imaging in the Neonatal Brain: From Advanced Doppler to Super-Resolution.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025Review
- Improving Imaging Field of View of 3-D Transcranial Rat Brain Super-Resolution With Robotic Registered Compounding and Nonrigid Deformation Correction.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025Article
- Combined Nanodrops Imaging and Ultrasound Localization Microscopy for Detecting Intracerebral Hemorrhage.Ultrasound in medicine & biology · 2025Article
- Ultrasound Super-Resolution Imaging of Neonatal Cerebral Vascular Reorganization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Optical coherence tomography enables longitudinal evaluation of cell graft-directed remodeling in stroke lesions.Experimental neurology · 2025Article
- Transcranial ultrasound localization microscopy in moyamoya patients using a clinical ultrasound system.Theranostics · 2025Article
- Comparison of high-frequency ultrasound transducers for microvascular localization microscopy in the mouse brain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Super-resolution ultrasound and microvasculomics: a consensus statement.European radiology · 2024Review
- Ultrasound Flow Imaging Study on Rat Brain with Ultrasound and Light Stimulations.Bioengineering (Basel, Switzerland) · 2024Article
- Non-invasive ultrasound localization microscopy (ULM) in azoospermia: connecting testicular microcirculation to spermatogenic functions.Theranostics · 2024Article
- Longitudinal 3-D Visualization of Microvascular Disruption and Perfusion Changes in Mice During the Evolution of Glioblastoma Using Super-Resolution Ultrasound.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Article
- Super-resolution ultrasound microvascular imaging: Is it ready for clinical use?Zeitschrift fur medizinische Physik · 2023Review
- Revealing vascular roadblocks in the brain.Nature · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
Early diagnosis is a critical part of the emergency care of cerebral hemorrhages and ischemia. A rapid and accurate diagnosis of strokes reduces the delays to appropriate treatments and a better functional recovery. Currently, CTscan and MRI are the gold standards with constraints of accessibility, availability, and possibly some contraindications. The development of Ultrasound Localization Microscopy (ULM) has enabled new perspectives to conventional transcranial ultrasound imaging with increased sensitivity, penetration depth, and resolution. The possibility of volumetric imaging has increased the field-of-view and provided a more precise description of the microvascularisation. In this study, rats (n = 9) were subjected to thromboembolic ischemic stroke or intracerebral hemorrhages prior to volumetric ULM at the early phases after onsets. Although the volumetric ULM performed in the early phase of ischemic stroke revealed a large hypoperfused area in the cortical area of the occluded artery, it showed a more diffused hypoperfusion in the hemorrhagic model. Respective computations of a Microvascular Diffusion Index highlighted different patterns of perfusion loss during the first 24 h of these two strokes' subtypes. Our study provides the first proof that this methodology should allow early discrimination between ischemic and hemorrhagic stroke with a potential toward diagnosis and monitoring in clinic.
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