ArticleNature communications2022
Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 96 citations in OpenAlex.
- A frequency-dependent phase-transition bioelectronic device with in-situ signal-filtering and Janus-adhesive capabilities for low-artifact sensing and tendon repair.Materials today. Bio · 2026Article
- A Peritoneum-Inspired Biomimetic Asymmetric Patch for Functional Repair and Anti-Adhesion in Abdominal Wall Defects.Advanced healthcare materials · 2026Article
- Bio-inspired programmable assembly of shape-memory and blood-reinforced cryogel for hemostasis and functional liver regeneration.Materials today. Bio · 2026Article
- Article
- Hemostatic Tough Adhesives seal tissue and control hemorrhage.Nature communications · 2026Article
- Ultra-fast self-gelling self-expanding self-propelling high-adhesion procoagulant hemostatic powder for non-compressible hemorrhage hemostasis in pigs.Nature communications · 2026Article
- Harnessing Polymeric Xerogels for Enhanced Wound Care: Properties, Mechanisms, and Applications.ACS materials Au · 2026Review
- rev-Gelatin: A Gelatin with Reverse Thermo-Responsive Behavior Inspired by Candy and Ice Cubes Phase Dynamics.Macromolecular bioscience · 2025Article
- Mechanoadaptive polysaccharide conjugates architect pro-healing microenvironments via dynamic stress redistribution in skin defects.Science advances · 2025Article
- Biomimetic 3D-Printed Adaptive Hydrogel Bioadhesives Featuring Superior Infection Resistance for Challenging Tissue Adhesion, Hemostasis, and Healthcare.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- A comprehensive review of unlocking the potential of lignin-derived biomaterials: from lignin structure to biomedical application.Journal of nanobiotechnology · 2025Review
- Covalently reactive microparticles imbibe blood to form fortified clots for rapid hemostasis and prevention of rebleeding.Nature communications · 2025Article
- Bicomponent nano- and microfiber aerogels for effective management of junctional hemorrhage.Nature communications · 2025Article
- Water absorption dynamics in medical foam: empirical validation of the Lucas-Washburn model.The European physical journal. E, Soft matter · 2025Article
- Bioinspired hierarchical porous tough adhesive to promote sealing of high-pressure bleeding.Bioactive materials · 2025Article
- An injectable, expandable polyacrylamide cryogel decreases blood loss and improves survival in a porcine model of junctional hemorrhage.Scientific reports · 2025Article
- Molecular self-assembly strategy tuning a dry crosslinking protein patch for biocompatible and biodegradable haemostatic sealing.Nature communications · 2025Article
- Glucose-responsive, self-healing, wet adhesive and multi-biofunctional hydrogels for diabetic wound healing.Materials today. Bio · 2024Article
- Superporous sponge prepared by secondary network compaction with enhanced permeability and mechanical properties for non-compressible hemostasis in pigs.Nature communications · 2024Article
- Non-Covalent Cross-Linking Hydrogel: A New Method for Visceral Hemostasis.Gels (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
Abstract
Non-compressible hemorrhage is an unmet clinical challenge that accounts for high mortality in trauma. Rapid pressurized blood flows under hemorrhage impair the function and integrity of hemostatic agents and the adhesion of bioadhesive sealants. Here, we report the design and performance of bioinspired microstructured bioadhesives, formed with a macroporous tough xerogel infused with functional liquids. The xerogel can rapidly absorb interfacial fluids such as whole blood and promote blood clotting, while the infused liquids facilitate interfacial bonding, sealing, and antibacterial function. Their synergy enables the bioadhesives to form tough adhesion on ex vivo human and porcine tissues and diverse engineered surfaces without the need for compression, as well as on-demand instant removal and storage stability. We demonstrate a significantly improved hemostatic efficacy and biocompatibility in rats and pigs compared to non-structured counterparts and commercial products. This work opens new avenues for the development of bioadhesives and hemostatic sealants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.