Evidence map›Paper›PMID 36028482›Full record

ArticleNature communications2022

Directed evolution of phosphite dehydrogenase to cycle noncanonical redox cofactors via universal growth selection platform.

Linyue Zhang, Edward King, William B Black, Christian M Heckmann, Allison Wolder, Youtian Cui, Francis Nicklen, Justin B Siegel, Ray Luo, Caroline E Paul and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Reversible enzyme-catalysed NADChemical science · 2025
    Article
  7. Article
  8. Regeneration of cofactor NAD(P)Frontiers in bioengineering and biotechnology · 2025
    Review
  9. Article
  10. EngineeringACS catalysis · 2024
    Article
  11. Review
  12. Article
  13. Article
  14. Exploring the Protein Sequence Space with Global Generative Models.Cold Spring Harbor perspectives in biology · 2023
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Linyue Zhang *Department of Chemical and Biomolecular Engineering, University of California Irvine, Irvine, CA, 92697, USA.
Edward King *Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, 92697, USA.
William B BlackDepartment of Chemical and Biomolecular Engineering, University of California Irvine, Irvine, CA, 92697, USA.
Christian M HeckmannBiocatalysis, Department of Biotechnology, Delft University of Technology, 2629 HZ, Delft, Netherlands.ORCID 0000-0003-0107-4477
Allison WolderBiocatalysis, Department of Biotechnology, Delft University of Technology, 2629 HZ, Delft, Netherlands.
Youtian CuiDepartment of Chemistry, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA.
Francis NicklenDepartment of Chemical and Biomolecular Engineering, University of California Irvine, Irvine, CA, 92697, USA.
Justin B SiegelDepartment of Chemistry, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA.
Ray LuoDepartment of Chemical and Biomolecular Engineering, University of California Irvine, Irvine, CA, 92697, USA.
Caroline E PaulBiocatalysis, Department of Biotechnology, Delft University of Technology, 2629 HZ, Delft, Netherlands.ORCID 0000-0002-7889-9920
Han LiDepartment of Chemical and Biomolecular Engineering, University of California Irvine, Irvine, CA, 92697, USA. han.li@uci.edu.ORCID 0000-0002-6113-6433
University of California, Irvine · USDelft University of Technology · NLUniversity of California, Davis · US

Funding

Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1987 to 2021
$50.1M
Enzymatic formation of the hydrocarbon skeletons underlying diterpenoid diversityR01GM076324 · NIGMS · IOWA STATE UNIVERSITY · PI PETERS, REUBEN JOHN · 2006 to 2019
$3.4M
Multi-scaled Modeling of Electrostatic and Polarization Effects in BiomoleculesR35GM130367 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI RAY LUO · 2019 to 2026
$3.0M
Engineering an unnatural redox cofactor (uRedox) system for efficient biosynthesis of medicinesDP2GM137427 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LI, HAN · 2019 to 2022
$2.4M
NIEHS NIH HHS P42 ES004699NIGMS NIH HHS DP2 GM137427NIGMS NIH HHS R01 GM076324NIGMS NIH HHS R35 GM130367
6 · The paper itself

Abstract

Noncanonical redox cofactors are attractive low-cost alternatives to nicotinamide adenine dinucleotide (phosphate) (NAD(P)

Indexed as

NADNADH, NADPH OxidoreductasesEscherichia coliNADPOxidation-ReductionNADNADH, NADPH OxidoreductasesNADPNAD phosphite oxidoreductase

Identifiers

PMID36028482
PMCPMC9418148
OpenAlexW4293109393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.