Evidence map›Paper›PMID 36028328›Full record

ArticleNeurology2022

Spatial Navigation and Its Association With Biomarkers and Future Dementia in Memory Clinic Patients Without Dementia.

Gro Gujord Tangen, Maria H Nilsson, Erik Stomrud, Sebastian Palmqvist, Oskar Hansson

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07225400 (Designing a Spatial Navigation Intervention Protocol Informed by Region-specific Brain Activation for Mild Cognitive Impairment), which is not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07225400 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Designing a Spatial Navigation Intervention Protocol Informed by Region-specific Brain Activation for Mild Cognitive Impairment

TypeinterventionalSponsorAlbert Einstein College of MedicineRan2026 to 2027Enrolled30ConditionsMild Cognitive Impairment (MCI)ArmsSpatial Navigation training
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. A Systematic Review of the Effects of Capsaicin on Alzheimer's Disease.International journal of molecular sciences · 2023
    Pooled it
  3. Trial
  4. Article
  5. Review
  6. Test-Retest Reliability of the Triangle Completion Test.Journal of the American Academy of Audiology · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Spatial memory and hippocampal remapping: Who will age well?Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Article
  16. Review
  17. Spatial orientation - a stable marker for vascular cognitive impairment?Cerebral circulation - cognition and behavior · 2023
    Article
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Gro Gujord TangenFrom the The Norwegian National Centre for Ageing and Health (G.G.T.), Vestfold Hospital Trust, Oslo ; Department of Geriatric Medicine (G.G.T.), Oslo University Hospital, Norway; Department of Health Sciences (M.H.N.), Lund Universityl Memory Clinic (M.H.N., E.S., S.P., O.H.), Skåne University Hospital, Malmö; and Clinical Memory Research Unit (M.H.N., E.S., S.P., O.H.), Department of Clinical Sciences Malmö, Lund University, Sweden. gro.tangen@aldringoghelse.no.ORCID 0000-0002-9417-2799
Maria H NilssonFrom the The Norwegian National Centre for Ageing and Health (G.G.T.), Vestfold Hospital Trust, Oslo ; Department of Geriatric Medicine (G.G.T.), Oslo University Hospital, Norway; Department of Health Sciences (M.H.N.), Lund Universityl Memory Clinic (M.H.N., E.S., S.P., O.H.), Skåne University Hospital, Malmö; and Clinical Memory Research Unit (M.H.N., E.S., S.P., O.H.), Department of Clinical Sciences Malmö, Lund University, Sweden.ORCID 0000-0002-6580-6721
Erik StomrudFrom the The Norwegian National Centre for Ageing and Health (G.G.T.), Vestfold Hospital Trust, Oslo ; Department of Geriatric Medicine (G.G.T.), Oslo University Hospital, Norway; Department of Health Sciences (M.H.N.), Lund Universityl Memory Clinic (M.H.N., E.S., S.P., O.H.), Skåne University Hospital, Malmö; and Clinical Memory Research Unit (M.H.N., E.S., S.P., O.H.), Department of Clinical Sciences Malmö, Lund University, Sweden.
Sebastian PalmqvistFrom the The Norwegian National Centre for Ageing and Health (G.G.T.), Vestfold Hospital Trust, Oslo ; Department of Geriatric Medicine (G.G.T.), Oslo University Hospital, Norway; Department of Health Sciences (M.H.N.), Lund Universityl Memory Clinic (M.H.N., E.S., S.P., O.H.), Skåne University Hospital, Malmö; and Clinical Memory Research Unit (M.H.N., E.S., S.P., O.H.), Department of Clinical Sciences Malmö, Lund University, Sweden.
Oskar HanssonFrom the The Norwegian National Centre for Ageing and Health (G.G.T.), Vestfold Hospital Trust, Oslo ; Department of Geriatric Medicine (G.G.T.), Oslo University Hospital, Norway; Department of Health Sciences (M.H.N.), Lund Universityl Memory Clinic (M.H.N., E.S., S.P., O.H.), Skåne University Hospital, Malmö; and Clinical Memory Research Unit (M.H.N., E.S., S.P., O.H.), Department of Clinical Sciences Malmö, Lund University, Sweden.
Oslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesImpaired spatial navigation is considered an early sign in many neurodegenerative diseases. We aimed to determine whether spatial navigation was associated with future dementia in patients with subjective cognitive decline (SCD) or mild cognitive impairment (MCI) and to explore associations between spatial navigation and biomarkers of Alzheimer disease (AD) and neurodegeneration.

methodsThis study included memory clinic patients without dementia in the longitudinal BioFINDER cohort. The Floor Maze Test (FMT) was used to assess spatial navigation at baseline. Conversion to dementia was evaluated at 2-year and 4-year follow-ups. At baseline, amyloid-β 42/40 ratio, phosphorylated-tau (P-tau), and neurofilament light (NfL) were analyzed in CSF. Cortical thickness and volume of regions relevant for navigation and white matter lesion volume were quantified from MRI. The predictive role of the FMT for conversion to all-cause dementia was analyzed using logistic regression analyses in 2 models: (1) controlled for age, sex, and education and (2) adding baseline cognitive status and MMSE. Associations between FMT and biomarkers were adjusted for age, sex, and cognitive status (SCD or MCI).

resultsOne hundred fifty-six patients with SCD and 176 patients with MCI were included. FMT total time was associated with progression to all-cause dementia in model 2 at 2-year (OR 1.10, 95% CI 1.04-1.16) and at 4-year follow-up (OR 1.10, 95% CI 1.04-1.16), i.e., a 10% increase in odds of developing dementia per every 10 seconds increase in FMT. In the adjusted analyses, P-tau and NfL were associated with FMT total time, as well as hippocampal volume, parahippocampal, and inferior parietal cortical thickness. Amyloid-β 42/40 ratio was not associated with FMT total time. DISCUSSION: Impaired spatial navigation was associated with conversion to dementia within 2 and 4 years and with key CSF and MRI biomarkers for AD and neurodegeneration in patients with SCD and MCI. This supports its use in early cognitive assessments, but the predictive accuracy should be validated in other cohorts. CLASSIFICATION OF EVIDENCE: This is a Class I prospective cohort study demonstrating association of baseline markers of spatial recognition with development of dementia in patients with SCD or MCI at baseline.

Indexed as

Alzheimer DiseaseCognitive DysfunctionSpatial NavigationAmyloid beta-PeptidesBiomarkersDisease ProgressionHumansProspective Studiestau ProteinsAmyloid beta-PeptidesBiomarkerstau Proteins

Identifiers

PMID36028328
PMCPMC9651458
OpenAlexW4293795080

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.