Evidence map›Paper›PMID 36028327›Full record

ArticleNeurology2022

Perception of Fragmented Letters by Patients With Pathologically Confirmed Dementia With Lewy Bodies or Alzheimer Disease.

David P Salmon, Denis S Smirnov, David G Coughlin, Joanne M Hamilton, Kelly M Landy, J Vincent Filoteo, Annie Hiniker, Lawrence A Hansen, Douglas Galasko

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Intrinsic capacity in Lewy body dementia: a review.The Journal of frailty & aging · 2025
    Review
  2. Article
  3. Visual dysfunction in dementia with Lewy bodies.Current neurology and neuroscience reports · 2024
    Review
  4. Optimizing cCOG, a Web-based tool, to detect dementia with Lewy Bodies.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

David P SalmonFrom the Department of Neurosciences (D.P.S., D.S.S., D.G.C., J.M.H., K.M.L., J.V.F., L.A.H., D.G.), Psychiatry (J.V.F.), and Pathology (A.H., L.A.H.), University of California, San Diego. dsalmon@ucsd.edu.
Denis S SmirnovFrom the Department of Neurosciences (D.P.S., D.S.S., D.G.C., J.M.H., K.M.L., J.V.F., L.A.H., D.G.), Psychiatry (J.V.F.), and Pathology (A.H., L.A.H.), University of California, San Diego.
David G CoughlinFrom the Department of Neurosciences (D.P.S., D.S.S., D.G.C., J.M.H., K.M.L., J.V.F., L.A.H., D.G.), Psychiatry (J.V.F.), and Pathology (A.H., L.A.H.), University of California, San Diego.
Joanne M HamiltonFrom the Department of Neurosciences (D.P.S., D.S.S., D.G.C., J.M.H., K.M.L., J.V.F., L.A.H., D.G.), Psychiatry (J.V.F.), and Pathology (A.H., L.A.H.), University of California, San Diego.
Kelly M LandyFrom the Department of Neurosciences (D.P.S., D.S.S., D.G.C., J.M.H., K.M.L., J.V.F., L.A.H., D.G.), Psychiatry (J.V.F.), and Pathology (A.H., L.A.H.), University of California, San Diego.
J Vincent FiloteoFrom the Department of Neurosciences (D.P.S., D.S.S., D.G.C., J.M.H., K.M.L., J.V.F., L.A.H., D.G.), Psychiatry (J.V.F.), and Pathology (A.H., L.A.H.), University of California, San Diego.
Annie HinikerFrom the Department of Neurosciences (D.P.S., D.S.S., D.G.C., J.M.H., K.M.L., J.V.F., L.A.H., D.G.), Psychiatry (J.V.F.), and Pathology (A.H., L.A.H.), University of California, San Diego.
Lawrence A HansenFrom the Department of Neurosciences (D.P.S., D.S.S., D.G.C., J.M.H., K.M.L., J.V.F., L.A.H., D.G.), Psychiatry (J.V.F.), and Pathology (A.H., L.A.H.), University of California, San Diego.
Douglas GalaskoFrom the Department of Neurosciences (D.P.S., D.S.S., D.G.C., J.M.H., K.M.L., J.V.F., L.A.H., D.G.), Psychiatry (J.V.F.), and Pathology (A.H., L.A.H.), University of California, San Diego.
Neurosciences Institute · US

Funding

UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jerome S. Mertens · 2019 to 2026
$34.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007198 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHI, NEIL C, INSEL, PAUL A · 1985 to 2024
$29.3M
Chemical-Genetic Approaches to Define Lrrk2 Kinase Function in Parkinson DiseaseK08NS090633 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HINIKER, ANNIE E · 2014 to 2018
$1.1M
Pathological and cognitive correlations of real time quaking induced conversion in LBD and ADK23NS120038 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COUGHLIN, DAVID G · 2021 to 2025
$828k
Repetition Priming Deficits and Locus Coeruleus Dysfunction in Alzheimer's DiseaseF30AG063440 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SMIRNOV, DENIS · 2019 to 2022
$179k
NIA NIH HHS F30 AG063440NIA NIH HHS P30 AG062429NIGMS NIH HHS T32 GM007198NINDS NIH HHS K08 NS090633NINDS NIH HHS K23 NS120038
6 · The paper itself

Abstract

BACKGROUND AND

objectivePatients with dementia with Lewy bodies perform worse than those with Alzheimer disease (AD) on tests of visual perception, but the clinical utility of these tests remains unknown because studies often had clinically diagnosed groups that may inadvertently cross-contaminate Lewy body disease (LBD) with pure AD pathology, used experimental tests not easily adaptable for clinical use, and had no way to examine relationships between the severity of LBD pathology and degree of cognitive impairment. Therefore, we sought to determine whether performance on a widely used clinical test of visuoperceptual ability effectively differentiates between patients with autopsy-confirmed LBD or AD and correlates with the severity of LBD pathology.

methodsPatients with mild to moderate dementia (n = 42) and cognitively healthy controls (n = 22) performed a Fragmented Letters Test in which they identified letters of the alphabet that were randomly visually degraded by 70% and additional visuospatial and episodic memory tests. At autopsy, dementia cases were confirmed to have LBD (n = 19), all with concomitant AD, or only AD (n = 23). Severity of α-synuclein pathology in the hippocampus and neocortex was rated on an ordinal scale.

resultsPatients with LBD performed worse than those with AD (B = -2.80 ± 0.91, DISCUSSION: Fragmented Letters Test performance can effectively differentiate patients with LBD pathology from those with only AD pathology at a mild to moderate stage of dementia, even when LBD occurs with significant concomitant AD pathology, and may also be useful for gauging the severity of cortical α-synuclein pathology in those with LBD.

Indexed as

Alzheimer DiseaseLewy Body Diseasealpha-SynucleinHumansLewy BodiesVisual Perceptionalpha-Synuclein

Identifiers

PMID36028327
PMCPMC9651460
OpenAlexW4293373917

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.