Evidence map›Paper›PMID 36028316›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Somatotopy of Mouse Spinothalamic Innervation and the Localization of a Noxious Stimulus Requires Deleted in Colorectal Carcinoma Expression by Phox2a Neurons.

Shima Rastegar-Pouyani, Timothy E Kennedy, Artur Kania

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shima Rastegar-PouyaniInstitut de Recherches Cliniques de Montréal, Montréal Québec H2W 1R7, Canada.
Timothy E KennedyIntegrated Program in Neuroscience, McGill University, Montréal Québec H3A 2B4, Canada.ORCID https://orcid.org/0000-0003-4454-5080
Artur KaniaInstitut de Recherches Cliniques de Montréal, Montréal Québec H2W 1R7, Canada artur.kania@ircm.qc.ca.ORCID https://orcid.org/0000-0002-5209-2520

Funding

CIHR MOP-77556CIHR PJT-153053CIHR PJT-159839CIHR PJT-162225
6 · The paper itself

Abstract

Anterolateral system (AS) neurons transmit pain signals from the spinal cord to the brain. Their morphology, anatomy, and physiological properties have been extensively characterized and suggest that specific AS neurons and their brain targets are concerned with the discriminatory aspects of noxious stimuli, such as their location or intensity, and their motivational/emotive dimension. Among the recently unraveled molecular markers of AS neurons is the developmentally expressed transcription factor Phox2a, providing us with the opportunity to selectively disrupt the embryonic wiring of AS neurons to gain insights into the logic of their adult function. As mice with a spinal-cord-specific loss of the netrin-1 receptor deleted in colorectal carcinoma (DCC) have increased AS neuron innervation of ipsilateral brain targets and defective noxious stimulus localization or topognosis, we generated mice of either sex carrying a deletion of

Indexed as

Colorectal NeoplasmsNerve Growth FactorsAnimalsDCC ReceptorHomeodomain ProteinsMiceNetrin-1Netrin ReceptorsNeuronsPainReceptors, Cell SurfaceThalamusTranscription FactorsTumor Suppressor ProteinsDCC ReceptorHomeodomain ProteinsNerve Growth FactorsNetrin-1Netrin ReceptorsPhox2a protein, mouseReceptors, Cell SurfaceTranscription FactorsTumor Suppressor Proteinsanterolateral systemDCCdevelopmentnociceptionPhox2atopognosis

Identifiers

PMID36028316
PMCPMC9617615

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.