Evidence map›Paper›PMID 36028313›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Trapping of Nicotinic Acetylcholine Receptor Ligands Assayed by

Hannah J Zhang, Matthew Zammit, Chien-Min Kao, Anitha P Govind, Samuel Mitchell, Nathanial Holderman, Mohammed Bhuiyan, Richard Freifelder, Anna Kucharski, Xiaoxi Zhuang and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Increased Binding of [Synapse (New York, N.Y.) · 2026
    Article
  3. Imaging [bioRxiv : the preprint server for biology · 2026
    Article
  4. Reduction in [Brain research · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Abnormal [Synapse (New York, N.Y.) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Hannah J ZhangDepartment of Radiology, University of Chicago, Chicago, Illinois 60637.
Matthew ZammitDepartment of Radiology, University of Chicago, Chicago, Illinois 60637.ORCID https://orcid.org/0000-0001-8966-8397
Chien-Min KaoDepartment of Radiology, University of Chicago, Chicago, Illinois 60637.
Anitha P GovindDepartment of Neurobiology, University of Chicago, Chicago, Illinois 60637.
Samuel MitchellDepartment of Radiology, University of Chicago, Chicago, Illinois 60637.
Nathanial HoldermanDepartment of Radiology, University of Chicago, Chicago, Illinois 60637.
Mohammed BhuiyanDepartment of Radiology, University of Chicago, Chicago, Illinois 60637.
Richard FreifelderDepartment of Radiology, University of Chicago, Chicago, Illinois 60637.
Anna KucharskiDepartment of Radiology, University of Chicago, Chicago, Illinois 60637.
Xiaoxi ZhuangDepartment of Neurobiology, University of Chicago, Chicago, Illinois 60637.
Jogeshwar MukherjeeDepartments of Preclinical Imaging and Radiological Sciences, University of California, Irvine, California 92697.
Chin-Tu ChenDepartment of Radiology, University of Chicago, Chicago, Illinois 60637 c-chen@uchicago.edu wgreen@uchicago.edu.
William N GreenDepartment of Neurobiology, University of Chicago, Chicago, Illinois 60637 c-chen@uchicago.edu wgreen@uchicago.edu.ORCID https://orcid.org/0000-0003-2167-1391
University of Chicago · USMarine Biological Laboratory · USUniversity of California, Irvine · US

Funding

PET imaging of a4b2 nicotinic receptor upregulation and smoking cessationR01DA044760 · NIDA · UNIVERSITY OF CHICAGO · PI CHEN, CHIN-TU, GREEN, WILLIAM · 2017 to 2021
$3.8M
Integrative Training in the Neurobiology of Addictive BehaviorsT32DA043469 · NIDA · UNIVERSITY OF CHICAGO · PI Donald Hedeker, Xiaoxi Zhuang · 2017 to 2026
$3.8M
PET Imaging agents for a4b2 Nicotinic ReceptorsRF1AG029479 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHRISTIAN, BRADLEY T, MUKHERJEE, JOGESHWAR · 2019 to 2020
$2.2M
Integrating Preclinical and Translational Imaging Resources for Animal ResearchS10OD025265 · OD · UNIVERSITY OF CHICAGO · PI CHEN, CHIN-TU · 2018 to 2018
$319k
NIA NIH HHS RF1 AG029479NIDA NIH HHS R01 DA044760NIDA NIH HHS T32 DA043469NIH HHS S10 OD025265
6 · The paper itself

Abstract

A question relevant to nicotine addiction is how nicotine and other nicotinic receptor membrane-permeant ligands, such as the anti-smoking drug varenicline (Chantix), distribute in brain. Ligands, like varenicline, with high pK

Indexed as

Receptors, NicotinicTobacco Use DisorderAnimalsBrainFemaleLigandsMaleMiceNicotinePositron-Emission TomographyVareniclineLigandsNicotineReceptors, NicotinicVareniclineaddictionfluorescencemouse modelnicotinepositron emission tomographysmoking cessation

Identifiers

PMID36028313
PMCPMC9838697
OpenAlexW4293155563

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.