Evidence map›Paper›PMID 36028121›Full record

ArticleMolecular metabolism2022

Adipose mTORC2 is essential for sensory innervation in white adipose tissue and whole-body energy homeostasis.

Irina C Frei, Diana Weissenberger, Danilo Ritz, Wolf Heusermann, Marco Colombi, Mitsugu Shimobayashi, Michael N Hall

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Irina C FreiBiozentrum, University of Basel, Basel 4056, Switzerland.
Diana WeissenbergerBiozentrum, University of Basel, Basel 4056, Switzerland.
Danilo RitzBiozentrum, University of Basel, Basel 4056, Switzerland.
Wolf HeusermannBiozentrum, University of Basel, Basel 4056, Switzerland.
Marco ColombiBiozentrum, University of Basel, Basel 4056, Switzerland.
Mitsugu ShimobayashiBiozentrum, University of Basel, Basel 4056, Switzerland. Electronic address: mitsugu.shimobayashi@kuleuven.be.
Michael N HallBiozentrum, University of Basel, Basel 4056, Switzerland. Electronic address: m.hall@unibas.ch.
University of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAdipose tissue, via sympathetic and possibly sensory neurons, communicates with the central nervous system (CNS) to mediate energy homeostasis. In contrast to the sympathetic nervous system, the morphology, role and regulation of the sensory nervous system in adipose tissue are poorly characterized. METHODS AND

resultsTaking advantage of recent progress in whole-mount three-dimensional imaging, we identified a network of calcitonin gene-related protein (CGRP)-positive sensory neurons in murine white adipose tissue (WAT). We found that adipose mammalian target of rapamycin complex 2 (mTORC2), a major component of the insulin signaling pathway, is required for arborization of sensory neurons, but not of sympathetic neurons. Time course experiments revealed that adipose mTORC2 is required for maintenance of sensory neurons. Furthermore, loss of sensory innervation in WAT coincided with systemic insulin resistance. Finally, we established that neuronal protein growth-associated protein 43 (GAP43) is a marker for sensory neurons in adipose tissue.

conclusionOur findings indicate that adipose mTORC2 is necessary for sensory innervation in WAT. In addition, our results suggest that WAT may affect whole-body energy homeostasis via sensory neurons.

Indexed as

Calcitonin Gene-Related PeptideInsulinsAdipose TissueAdipose Tissue, WhiteAnimalsCalcitoninGAP-43 ProteinHomeostasisMammalsMechanistic Target of Rapamycin Complex 2MiceSensory Receptor CellsTOR Serine-Threonine KinasesCalcitoninCalcitonin Gene-Related PeptideGAP-43 ProteinInsulinsMechanistic Target of Rapamycin Complex 2TOR Serine-Threonine KinasesAdipose tissueCGRPDiabetesmTORC2NeuropathySensory nervous systemWhole-body energy homeostasis

Identifiers

PMID36028121
PMCPMC9472075
OpenAlexW4292821696

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.