Evidence map›Paper›PMID 36027629›Full record

ReviewThrombosis research2022

Challenging clinical scenarios for therapeutic anticoagulation: A practical approach.

Kylee L Martens, Simone E Dekker, Megan Crowe, Thomas G DeLoughery, Joseph J Shatzel

Open access · greenAbstract readReview
In one paragraph

Review in Thrombosis research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kylee L MartensDivision of Hematology-Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, United States of America. Electronic address: martenky@ohsu.edu.
Simone E DekkerDivision of Internal Medicine, Oregon Health & Science University, Portland, OR, United States of America.
Megan CroweDivision of Internal Medicine, Oregon Health & Science University, Portland, OR, United States of America.
Thomas G DeLougheryDivision of Hematology-Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, United States of America.
Joseph J ShatzelDivision of Hematology-Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, United States of America.
Oregon Health & Science University · US

Funding

Evaluating the Safety and Efficacy of Targeting the Contact Pathway to Prevent Device Associated Thrombosis.R01HL151367 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI SHATZEL, JOSEPH JAMES · 2020 to 2024
$1.5M
NHLBI NIH HHS R01 HL151367
6 · The paper itself

Abstract

Therapeutic anticoagulation remains a fundamental backbone in the treatment and prevention of venous thromboembolism. However, while modern therapies are increasingly safe, anticoagulation is not without risks, particularly in those at high risk for or with recent bleeding. When weighing concurrent risks and benefits in each challenging clinical scenario, an individualized assessment of the risk and acuity of bleeding should be balanced by the indication for anticoagulation. Addressing modifiable risk factors and routine re-evaluation of any changes in this balance is critical. This review outlines available data and current guidelines for the management of anticoagulation in high-risk populations, including those with thrombocytopenia, elderly and high-fall risk, inherited bleeding disorders, and in acute coronary syndrome. We also examine management after clinically significant bleeding episodes, including intracranial hemorrhage, gastrointestinal bleeding, hemoptysis, retroperitoneal bleeding, hematuria, and abnormal uterine bleeding. The aim is to provide a comprehensive review of available literature to guide clinicians in providing optimal, safe, and individualized care for patients in these challenging scenarios.

Indexed as

ThrombocytopeniaVenous ThromboembolismAgedAnticoagulantsBlood CoagulationHemorrhageHumansAnticoagulantsAnticoagulation managementThrombosis and hemostasis

Identifiers

PMID36027629
PMCPMC9481720
OpenAlexW4292240066

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.