ArticlePLoS neglected tropical diseases2022
Genomic characterization of invasive typhoidal and non-typhoidal Salmonella in southwestern Nigeria.
Article in PLoS neglected tropical diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Emergence of Genotype 2.3.1 Multidrug-Resistant Salmonella enterica Serovar Typhi Strain, West Africa, 2021-2025.Emerging infectious diseases · 2026Article
- ReGAIN: a bioinformatics platform for assessing probabilistic co-occurrence between resistance genes in bacterial pathogens.Bioinformatics (Oxford, England) · 2026Article
- Isolation and characterization of a novel lytic phage Artin targeting typhoidal and nontyphoidal Salmonella and evaluation of its antibacterial efficacy in food.Virology journal · 2026Article
- Prevalence and molecular characterization of Salmonella spp. from clinical, food, and environmental sources in Addis Ababa and surrounding towns, Ethiopia.BMC microbiology · 2026Article
- Serovars, Genetic Relatedness and Antimicrobial Resistance of Non-TyphoidalMicroorganisms · 2026Article
- Article
- Assessing the Genomic Landscape of Salmonella enterica Isolated From Cattle Faeces on a Nigerian Farm.MicrobiologyOpen · 2025Article
- Laboratory epidemiology ofOne health (Amsterdam, Netherlands) · 2025Article
- Antibiotic susceptibility patterns of clinical isolates of salmonella species producing extended spectrum beta lactamases as predictor of multidrug resistance in a tertiary hospital, Southeastern Nigeria.BMC infectious diseases · 2025Article
- Typhi Mykrobe: fast and accurate lineage identification and antimicrobial resistance genotyping directly from sequence reads for the typhoid fever agent Salmonella Typhi.Genome medicine · 2025Article
- Whole-Genome Sequencing Analysis of Drug-ResistantPathogens (Basel, Switzerland) · 2025Article
- Epidemiology of NontyphoidalAnnals of laboratory medicine · 2025Article
- Article
- Slow-growing Salmonella enterica serovariety Typhi mis-identified as serovariety Gallinarum in Ibadan, Nigeria.PLOS global public health · 2025Article
- Sociodemographic and clinical factors influencing typhoid fever prevalence and multidrug resistance in Niger State, Nigeria.PloS one · 2025Article
- Frequency and antibiotic resistance pattern ofIranian journal of microbiology · 2024Article
- Comparative genomic analysis provides new insights into non-typhoidal Salmonella population structure in Peru.Scientific reports · 2024Article
- Assessing antimicrobial resistance profiles ofJournal of medical microbiology · 2024Article
- Antimicrobial Resistance and Phylogenetic Relatedness ofMicroorganisms · 2024Article
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21 authors.
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Abstract
backgroundSalmonellosis causes significant morbidity and mortality in Africa. Information on lineages of invasive Salmonella circulating in Nigeria is sparse.
methodsSalmonella enterica isolated from blood (n = 60) and cerebrospinal fluid (CSF, n = 3) between 2016 and 2020 from five tertiary hospitals in southwest Nigeria were antimicrobial susceptibility-tested and Illumina-sequenced. Genomes were analysed using publicly-available bioinformatic tools.
resultsIsolates and sequence types (STs) from blood were S. Typhi [ST1, n = 1 and ST2, n = 43] and invasive non-typhoidal Salmonella (iNTS) (S. Enteritidis [ST11, n = 7], S. Durham [ST10, n = 2], S. Rissen [ST8756, n = 2], S. Chester [ST2063, n = 1], S. Dublin [ST10, n = 1], S. Infantis [ST603, n = 1], S. Telelkebir [ST8757, n = 1] and S. Typhimurium [ST313, n = 1]). S. Typhi ST2 (n = 2) and S. Adabraka ST8757 (n = 1) were recovered from CSF. Most S. Typhi belonged to genotype 3.1.1 (n = 44), carried an IncY plasmid, had several antibiotic resistance genes (ARGs) including blaTEM-1 (n = 38), aph(6)-Id (n = 32), tet(A) (n = 33), sul2 (n = 32), dfrA14 (n = 30) as well as quinolone resistance-conferring gyrA_S83Y single-nucleotide polymorphisms (n = 37). All S. Enteritidis harboured aph(3")-Ib, blaTEM-1, catA1, dfrA7, sul1, sul2, tet(B) genes, and a single ARG, qnrB19, was detected in S. Telelkebir. Typhoidal toxins cdtB, pltA and pltB were detected in S. Typhi, Rissen, Chester, and Telelkebir.
conclusionMost invasive salmonelloses in southwest Nigeria are vaccine-preventable infections due to multidrug-resistant, West African dominant S. Typhi lineage 3.1.1. Invasive NTS serovars, including some harbouring typhoidal toxin or resistance genes, represented a third of the isolates emphasizing the need for better diagnosis and surveillance.
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