Evidence map›Paper›PMID 36018837›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Single-neuron bursts encode pathological oscillations in subcortical nuclei of patients with Parkinson's disease and essential tremor.

Maximilian Scherer, Leon A Steiner, Suneil K Kalia, Mojgan Hodaie, Andrea A Kühn, Andres M Lozano, William D Hutchison, Luka Milosevic

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 50 citations in OpenAlex.

  1. Essential Tremor Suppression with a Novel Anti-Tremor Orthosis: A Randomized Crossover Trial.Movement disorders : official journal of the Movement Disorder Society · 2025
    Trial
  2. Article
  3. Article
  4. From continuous to adaptive deep brain stimulation: Personalized modulation improves motor complications and sleep in Parkinson's Disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Oscillatory Coupling Between Thalamus, Cerebellum, and Motor Cortex in Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Clinical neurophysiology in the treatment of movement disorders: IFCN handbook chapter.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Maximilian SchererKrembil Brain Institute, University Health Network, Toronto, M5T 2S8, Canada.ORCID 0000-0002-5280-2828
Leon A SteinerKrembil Brain Institute, University Health Network, Toronto, M5T 2S8, Canada.
Suneil K KaliaKrembil Brain Institute, University Health Network, Toronto, M5T 2S8, Canada.
Mojgan HodaieKrembil Brain Institute, University Health Network, Toronto, M5T 2S8, Canada.ORCID 0000-0001-6278-4929
Andrea A KühnDepartment of Neurology, Charité-Universitätsmedizin Berlin, Berlin, 10117, Germany.ORCID 0000-0002-4134-9060
Andres M LozanoKrembil Brain Institute, University Health Network, Toronto, M5T 2S8, Canada.
William D HutchisonKrembil Brain Institute, University Health Network, Toronto, M5T 2S8, Canada.ORCID 0000-0002-3866-4940
Luka MilosevicKrembil Brain Institute, University Health Network, Toronto, M5T 2S8, Canada.ORCID 0000-0002-4051-5397
University Health Network · CACharité - Universitätsmedizin Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deep brain stimulation procedures offer an invaluable opportunity to study disease through intracranial recordings from awake patients. Here, we address the relationship between single-neuron and aggregate-level (local field potential; LFP) activities in the subthalamic nucleus (STN) and thalamic ventral intermediate nucleus (Vim) of patients with Parkinson's disease (

Indexed as

Essential TremorNeuronsParkinson DiseaseSubthalamic NucleusBeta RhythmDeep Brain StimulationHumanslocal field potentialsmovement disorderssingle neuronssubthalamic nucleusventral intermediate thalamus

Identifiers

PMID36018837
PMCPMC9436336
OpenAlexW4293149801

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.