Evidence map›Paper›PMID 36018823›Full record

ArticleBiology of reproduction2022

Ferumoxytol dynamic contrast enhanced magnetic resonance imaging identifies altered placental cotyledon perfusion in rhesus macaques†.

Daniel P Seiter, Sydney M Nguyen, Terry K Morgan, Lu Mao, Dawn M Dudley, David H O'connor, Megan E Murphy, Kai D Ludwig, Ruiming Chen, Archana Dhyani and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology of reproduction, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. BRIDGING COTYLEDON PATHOLOGY AND PERFUSION IN HEALTHY PRIMATE PREGNANCY.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Ferumoxytol-enhanced cardiovascular magnetic resonance imaging: applications and technical advances.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
    Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Daniel P SeiterDepartment of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA.
Sydney M NguyenDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, USA.
Terry K MorganDepartment of Pathology, Oregon Health & Science University, Portland, OR, USA.
Lu MaoDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.
Dawn M DudleyDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA.
David H O'connorWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Megan E MurphyDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, USA.
Kai D LudwigDepartment of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA.
Ruiming ChenDepartment of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA.
Archana DhyaniDepartment of Computer Science, University of Wisconsin-Madison, Madison, WI, USA.
Ante ZhuDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA.
Michele L SchotzkoWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Kevin G BrunnerWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Dinesh M ShahDepartment of Obstetrics & Gynecology, University of Wisconsin-Madison, Madison, WI, USA.
Kevin M JohnsonDepartment of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA.
Thaddeus G GolosDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, USA.
Oliver WiebenDepartment of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA.
University of Wisconsin–Madison · USOregon Health & Science University · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Advanced MRI FOR Uteroplacental Flow, Perfusion, Oxygenation & InflammationU01HD087216 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI SHAH, DINESH MANILAL, WIEBEN, OLIVER · 2015 to 2015
$4.0M
Magnetic resonance imaging of the antecedents of fetal growth restriction at the primate maternal-fetal interfaceR01HD103443 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI SHAH, DINESH MANILAL, WIEBEN, OLIVER · 2020 to 2024
$3.2M
Endocrinology-Reproductive Physiology Training GrantT32HD041921 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI BIRD, IAN M. · 2004 to 2022
$3.0M
Nonhuman Primate Model to Assess Fetal Zika Virus Infection ComplicationsR21AI129308 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GOLOS, THADDEUS G · 2017 to 2018
$405k
NIAID NIH HHS R21 AI129308NICHD NIH HHS R01 HD103443NICHD NIH HHS T32 HD041921NICHD NIH HHS U01 HD087216NIH HHS P51 OD011106NIH HHS R01 Al116382ODCDC CDC HHS P51 OD011106
6 · The paper itself

Abstract

Identification of placental dysfunction in early pregnancy with noninvasive imaging could be a valuable tool for assessing maternal and fetal risk. Dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) can be a powerful tool for interrogating placenta health. After inoculation with Zika virus or sham inoculation at gestation age (GA) 45 or 55 days, animals were imaged up to three times at GA65, GA100, and GA145. DCE MRI images were acquired at all imaging sessions using ferumoxytol, an iron nanoparticle-based contrast agent, and analyzed for placental intervillous blood flow, number of perfusion domains, and perfusion domain volume. Cesarean section was performed at GA155, and the placenta was photographed and dissected for histopathology. Photographs were used to align cotyledons with estimated perfusion domains from MRI, allowing comparison of estimated cotyledon volume to pathology. Monkeys were separated into high and low pathology groups based on the average number of pathologies present in the placenta. Perfusion domain flow, volume, and number increased through gestation, and total blood flow increased with gestation for both low pathology and high pathology groups. A statistically significant decrease in perfusion domain volume associated with pathology was detected at all gestational ages. Individual perfusion domain flow comparisons demonstrated a statistically significant decrease with pathology at GA100 and GA145, but not GA65. Since ferumoxytol is currently used to treat anemia during human pregnancy and as an off-label MRI contrast agent, future transition of this work to human pregnancy may be possible.

Indexed as

Zika VirusZika Virus InfectionAnimalsCesarean SectionContrast MediaFemaleFerrosoferric OxideHumansMacaca mulattaMagnetic Resonance ImagingPerfusionPlacentaPregnancyContrast MediaFerrosoferric Oxideblood flowcontrast enhancedcotyledonferumoxytolgestationmagnetic resonance imagingMRIpathologyperfusionperfusion domainplacentarhesus macaqueZika virus

Identifiers

PMID36018823
PMCPMC9752971
OpenAlexW4293149881

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.