Evidence map›Paper›PMID 36018539›Full record

ReviewEndocrine2022

Radioligand therapy (RLT) as neoadjuvant treatment for inoperable pancreatic neuroendocrine tumors: a literature review.

Luca Urso, Alberto Nieri, Ilaria Rambaldi, Angelo Castello, Licia Uccelli, Corrado Cittanti, Stefano Panareo, Irene Gagliardi, Maria Rosaria Ambrosio, Maria Chiara Zatelli and 1 more

Open access · hybridAbstract readReview
In one paragraph

Review in Endocrine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. LutatheraPharmaceutics · 2023
    Review
  8. Relevance of Volumetric Parameters Applied to [Diagnostics (Basel, Switzerland) · 2023
    Article
  9. Article
  10. Detection of Bone Metastases byContrast media & molecular imaging · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Luca UrsoNuclear Medicine Unit, Department of Oncology and Specialist Medicines, University Hospital of Ferrara, Ferrara, Italy.
Alberto NieriNuclear Medicine Unit, Department of Oncology and Specialist Medicines, University Hospital of Ferrara, Ferrara, Italy.
Ilaria RambaldiNuclear Medicine Unit, Department of Oncology and Specialist Medicines, University Hospital of Ferrara, Ferrara, Italy.
Angelo CastelloDepartment of Nuclear Medicine, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Licia UccelliNuclear Medicine Unit, Department of Oncology and Specialist Medicines, University Hospital of Ferrara, Ferrara, Italy.
Corrado CittantiNuclear Medicine Unit, Department of Oncology and Specialist Medicines, University Hospital of Ferrara, Ferrara, Italy.
Stefano PanareoNuclear Medicine Unit, Oncology and Haematology Department, University Hospital of Modena, Modena, Italy.
Irene GagliardiSection of Endocrinology, Geriatric and Internal Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Maria Rosaria AmbrosioSection of Endocrinology, Geriatric and Internal Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Maria Chiara ZatelliSection of Endocrinology, Geriatric and Internal Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, Italy. ztlmch@unife.it.ORCID 0000-0001-8408-7796
Mirco BartolomeiNuclear Medicine Unit, Department of Oncology and Specialist Medicines, University Hospital of Ferrara, Ferrara, Italy.
University of Ferrara · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the last 10 years, several literature reports supported radioligand therapy (RLT) in neoadjuvant settings for pancreatic neuroendocrine tumors (PanNETs). Indeed, primary tumor shrinkage has been frequently reported following RLT in unresectable or borderline resectable PanNETs. Moreover, RLT-induced intratumoral modifications facilitate surgery, both on primary tumor and metastasis, having a great impact on progression free survival (PFS), overall survival (OS) and quality of life (QoL). However, prospective controlled investigations are necessary to confirm preliminary data and to define the best RLT scheme and the ideal patient that, in a multidisciplinary approach, should be referred to neoadjuvant RLT.

Indexed as

Neuroendocrine TumorsPancreatic NeoplasmsHumansNeoadjuvant TherapyProspective StudiesQuality of Life177Lu90YNeoadjuvant TherapyNeuroendocrine TumorsPancreatic SurgeryPeptide Receptor Radionuclide TherapyRadioligand Therapy

Identifiers

PMID36018539
PMCPMC9585010
OpenAlexW4293175944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.