Evidence map›Paper›PMID 36018525›Full record

ArticleAnnals of surgical oncology2022

Very Early Recurrence After Curative-Intent Surgery for Gastric Adenocarcinoma.

Gaya Spolverato, Giulia Capelli, Valentina Mari, Giulia Lorenzoni, Dario Gregori, George Poultsides, Ryan C Fields, Sharon M Weber, Konstantinos Votanopoulos, Clifford S Cho and 4 more

Abstract read
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In one paragraph

Article in Annals of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Defining a Nomogram for Predicting Early Recurrence in Gastric Cancer Patients After Neoadjuvant Chemotherapy and Radical Gastrectomy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 2 countries.

Gaya SpolveratoDepartment of Surgical Oncological and Gastrointestinal Science, University of Padova, Padova, Italy.
Giulia CapelliDepartment of Surgical Oncological and Gastrointestinal Science, University of Padova, Padova, Italy.
Valentina MariDepartment of Surgical Oncological and Gastrointestinal Science, University of Padova, Padova, Italy.
Giulia LorenzoniDepartment of Surgical Oncological and Gastrointestinal Science, University of Padova, Padova, Italy.
Dario GregoriDepartment of Surgical Oncological and Gastrointestinal Science, University of Padova, Padova, Italy.
George PoultsidesDepartment of Surgery, Stanford University, Stanford, CA, USA.
Ryan C FieldsDepartment of Surgery, Washington University, St. Louis, MO, USA.
Sharon M WeberDivision of Surgical Oncology, Department of Surgery, University of Wisconsin, Madison, WI, USA.
Konstantinos VotanopoulosDepartment of Surgery, Wake Forest University, Winston-Salem, NC, USA.
Clifford S ChoDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Jin HeDepartment of Surgery, Johns Hopkins Hospital, Baltimore, MD, USA.
Shishir K MaithelDivision of Surgical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Salvatore PucciarelliDepartment of Surgical Oncological and Gastrointestinal Science, University of Padova, Padova, Italy.
Timothy M PawlikDepartment of Surgery, The Urban Meyer III and Shelley Meyer Chair for Cancer Research, The Ohio State Wexner Medical Center, The Ohio State University, Columbus, OH, USA. tim.pawlik@osumc.edu.ORCID http://orcid.org/0000-0002-7994-9870
University of Padua · ITEmory University · USJohns Hopkins Hospital · USStanford University · USThe Ohio State University Wexner Medical Center · USUniversity of Michigan · USUniversity of Wisconsin–Madison · USWake Forest University · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecurrence after curative-intent surgery can occur in more than 50% of gastric cancer (GC) patients. We sought to identify predictors of very early recurrence (VER) among GC patients who underwent curative-intent surgery.

methodsA multi-institutional database of GC patients undergoing curative-intent surgery between 2000 and 2020 at 8 major institutions was queried. VER was defined as local or distant tumor recurrence within 6 months from surgery. Univariable Cox proportional hazard models were used to evaluate the predictive value of clinical-pathological features on VER. A regularized Cox regression model was employed to build a predictive model of VER and recurrence within 12 months. The discriminant ability of the Cox regularized models was evaluated by reporting a ROC curve together with the calibration plot, considering 200 runs.

resultsAmong 1133 patients, 65 (16.0%) patients experienced a VER. Preoperative symptoms (HR 1.198), comorbidities (HR 1.289), tumor grade (HR 1.043), LNR (HR 4.339) and T stage (HR 1.639) were associated with an increased likelihood of VER. Model performance was very good at predicting VER at 6 months (AUC of 0.722) and 12 months (AUC 0.733). Two nomograms to predict 6-month and 12-month VER were built based on the predictive model. A higher nomogram score was associated with worse prognosis. There was good prediction between observed and estimated VER with minimal evidence of overfitting and good performance on internal bootstrapping validation.

conclusionOne in 6 patients experienced VER following curative-intent surgery for GC. Nomograms to predict risk of VER performed well on internal validation, and stratified patients into distinct prognostic groups relative to 6- and 12-months recurrence.

Indexed as

AdenocarcinomaStomach NeoplasmsHumansNeoplasm Recurrence, LocalNomogramsPrognosisRetrospective Studies

Identifiers

PMID36018525
OpenAlexW4293124898

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.