Evidence map›Paper›PMID 36018181›Full record

ArticleNeural regeneration research2023

Association between brain N-acetylaspartate levels and sensory and motor dysfunction in patients who have spinal cord injury with spasticity: an observational case-control study.

Jia-Yi Liu, Ya-Jing Li, Xin-Ying Cong, Zuliyaer Talifu, Xin Zhang, Feng Gao, Jian-Jun Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. The Emerging Role of N-Acetylaspartate in Cancer.International journal of molecular sciences · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Jia-Yi LiuSchool of Rehabilitation, Capital Medical University; Department of Spinal and Neural Function Reconstruction, China Rehabilitation Research Center; China Rehabilitation Science Institute; Beijing Key Laboratory of Neural Injury and Rehabilitation; Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China.
Ya-Jing LiRehabilitation Department, Shanghai Huashan Hospital, Shanghai, China.
Xin-Ying CongDepartment of Medical Imaging, China Rehabilitation Research Center, Beijing, China.
Zuliyaer TalifuSchool of Rehabilitation, Capital Medical University; Department of Spinal and Neural Function Reconstruction, China Rehabilitation Research Center; China Rehabilitation Science Institute; Beijing Key Laboratory of Neural Injury and Rehabilitation; Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China.
Xin ZhangSchool of Rehabilitation, Capital Medical University; Department of Spinal and Neural Function Reconstruction, China Rehabilitation Research Center; China Rehabilitation Science Institute; Beijing Key Laboratory of Neural Injury and Rehabilitation; Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China.
Feng GaoSchool of Rehabilitation, Capital Medical University; Department of Spinal and Neural Function Reconstruction, China Rehabilitation Research Center; China Rehabilitation Science Institute; Beijing Key Laboratory of Neural Injury and Rehabilitation; Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China.
Jian-Jun LiSchool of Rehabilitation, Capital Medical University; Department of Spinal and Neural Function Reconstruction, China Rehabilitation Research Center; China Rehabilitation Science Institute; Beijing Key Laboratory of Neural Injury and Rehabilitation; Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China.
China Rehabilitation Research Center · CNChinese Institute for Brain Research · CNCapital Medical University · CNHuashan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury is a severe and devastating disease, and spasticity is a common and severe complication that is notoriously refractory to treatment. However, the pathophysiological mechanisms underlying spasticity and its development remain largely unknown. The goal of the present study was to find differences, if any, in metabolites of the left precentral gyrus and basal ganglia of patients who have spinal cord injury with or without spasticity, and to explore the relationship between the brain metabolite concentrations and clinical status. Thirty-six participants were recruited for magnetic resonance spectroscopic examination: 23 with spinal cord injury (12 with spasticity and 11 without spasticity) and 13 healthy controls. We acquired localized proton spectra from the precentral gyrus and basal ganglia via 10 mm

Indexed as

ASIA motor scoreASIA sensory scorebasal gangliacentral nervous systemduration of injurymagnetic resonance spectroscopyN-acetylaspartateprecentral gyrusspasticityspinal cord injury

Identifiers

PMID36018181
PMCPMC9727442
OpenAlexW4292581597

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.