Evidence map›Paper›PMID 36018039›Full record

ArticleACS infectious diseases2022

Anti-persister and Anti-biofilm Activity of Self-Assembled Antimicrobial Peptoid Ellipsoidal Micelles.

Jennifer S Lin, Laurent A Bekale, Natalia Molchanova, Josefine Eilsø Nielsen, Megan Wright, Brian Bacacao, Gill Diamond, Håvard Jenssen, Peter L Santa Maria, Annelise E Barron

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Antimicrobial Peptide-Peptoid Macrocycles from the Polymyxin B2 Chemical Space.Angewandte Chemie (International ed. in English) · 2025
    Article
  9. Article
  10. Antibiotic-recalcitrant Salmonella during infection.Nature reviews. Microbiology · 2025
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. The activity of antimicrobial peptoids against multidrug-resistant ocular pathogens.Contact lens & anterior eye : the journal of the British Contact Lens Association · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Jennifer S LinDepartment of Bioengineering, School of Medicine & School of Engineering, Stanford University, Stanford, California 94305, United States.ORCID 0000-0001-9169-7410
Laurent A BekaleDepartment of Otolaryngology, Head and Neck Surgery, School of Medicine, Stanford University, Stanford, California 94305, United States.ORCID 0000-0001-5059-5442
Natalia MolchanovaThe Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Josefine Eilsø NielsenDepartment of Bioengineering, School of Medicine & School of Engineering, Stanford University, Stanford, California 94305, United States.ORCID 0000-0001-9274-5533
Megan WrightDepartment of Otolaryngology, Head and Neck Surgery, School of Medicine, Stanford University, Stanford, California 94305, United States.
Brian BacacaoDepartment of Otolaryngology, Head and Neck Surgery, School of Medicine, Stanford University, Stanford, California 94305, United States.
Gill DiamondDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, Kentucky 40202, United States.
Håvard JenssenDepartment of Science and Environment, Roskilde University, 4000 Roskilde, Denmark.ORCID 0000-0003-0007-0335
Peter L Santa MariaDepartment of Otolaryngology, Head and Neck Surgery, School of Medicine, Stanford University, Stanford, California 94305, United States.
Annelise E BarronDepartment of Bioengineering, School of Medicine & School of Engineering, Stanford University, Stanford, California 94305, United States.ORCID 0000-0002-0735-6873
Stanford University · USRoskilde University · DKLawrence Berkeley National Laboratory · USUniversity of Louisville · US

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS · 2017 to 2026
$28.6M
Role of Innate Immune Dysregulation in the Etiology of DementiaDP1AG072438 · NIA · STANFORD UNIVERSITY · PI BARRON, ANNELISE EMILY · 2020 to 2024
$5.2M
A Pixel Array Detector System for Small Angle X-ray ScatteringS10OD018483 · OD · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI CLASSEN, SCOTT · 2014 to 2014
$998k
Synthetic Antimicrobial Peptoids for Treatment of Chronic Suppurative Otitis MediaR41DC020077 · NIDCD · MAXWELL BIOSCIENCES, INC. · PI BARRON, ANNELISE EMILY, KIRSHENBAUM, KENT W · 2021 to 2021
$257k
NIA NIH HHS DP1 AG072438NIDCD NIH HHS R41 DC020077NIGMS NIH HHS P30 GM124169NIH HHS S10 OD018483
6 · The paper itself

Abstract

Although persister cells are the root cause of resistance development and relapse of chronic infections, more attention has been focused on developing antimicrobial agents against resistant bacterial strains than on developing anti-persister agents. Frustratingly, the global preclinical antibacterial pipeline does not include any anti-persister drug. Therefore, the central point of this work is to explore antimicrobial peptidomimetics called peptoids (sequence-specific oligo-

Indexed as

Anti-Infective AgentsPeptoidsAnti-Bacterial AgentsHumansMicellesMicrobial Sensitivity TestsRecurrenceAnti-Bacterial AgentsAnti-Infective AgentsMicellesPeptoidsantibacterialbiofilmmicellespeptoidspersister cells

Identifiers

PMID36018039
PMCPMC9469094
OpenAlexW4293116190

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.