Evidence map›Paper›PMID 36017891›Full record

ArticleActa biochimica et biophysica Sinica2022

A positive feedback loop of ARF6 activates ERK1/2 signaling pathway via

Bingkai Xiao, Yue Zhang, Zekun Lu, Weibo Chen, Yong An, Guangchen Zu, Xiaowu Xu, Di Wu, Hao Yang, Yi Qin and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Bingkai XiaoDepartment of Hepatopancreatobiliary Surgery, the Third Affiliated Hospital of Soochow University, Changzhou 213000, China.
Yue ZhangDepartment of Hepatopancreatobiliary Surgery, the Third Affiliated Hospital of Soochow University, Changzhou 213000, China.
Zekun LuDepartment of Hepatopancreatobiliary Surgery, the Third Affiliated Hospital of Soochow University, Changzhou 213000, China.
Weibo ChenDepartment of Hepatopancreatobiliary Surgery, the Third Affiliated Hospital of Soochow University, Changzhou 213000, China.
Yong AnDepartment of Hepatopancreatobiliary Surgery, the Third Affiliated Hospital of Soochow University, Changzhou 213000, China.
Guangchen ZuDepartment of Hepatopancreatobiliary Surgery, the Third Affiliated Hospital of Soochow University, Changzhou 213000, China.
Xiaowu XuDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Di WuDepartment of Hepatopancreatobiliary Surgery, the Third Affiliated Hospital of Soochow University, Changzhou 213000, China.
Hao YangDepartment of Hepatopancreatobiliary Surgery, the Third Affiliated Hospital of Soochow University, Changzhou 213000, China.
Yi QinDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Xuemin ChenDepartment of Hepatopancreatobiliary Surgery, the Third Affiliated Hospital of Soochow University, Changzhou 213000, China.
Soochow University · CNFudan University Shanghai Cancer Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ERK1/2 are essential proteins mediating mitogen-activated protein kinase signaling downstream of RAS in pancreatic adenocarcinoma (PDAC). Our previous study reveals that ARF6 plays a positive regulatory role in ERK1/2 pathway in a feedback loop manner. A significant part of the literature on ARF6 has emphasized its oncogenic effect as an essential downstream molecule of ERK1/2, and no research has been done on the regulation mechanisms of the feedback loop between ARF6 and the ERK1/2 signaling pathway. In the present study, we explore the gene network downstream of

Indexed as

AdenocarcinomaPancreatic NeoplasmsDual Specificity Phosphatase 6FeedbackHumansMAP Kinase Signaling SystemMitogen-Activated Protein Kinase 1Signal TransductionDual Specificity Phosphatase 6DUSP6 protein, humanMitogen-Activated Protein Kinase 1ARF6DUSP6ERK1/2 pathwaypancreatic adenocarcinoma

Identifiers

PMID36017891
PMCPMC9827993
OpenAlexW4295004732

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.