Evidence map›Paper›PMID 36017889›Full record

ArticleActa biochimica et biophysica Sinica2022

AHNAK2 is a biomarker and a potential therapeutic target of adenocarcinomas.

Meng Xu, Anyi Cheng, Liya Yu, Wei Wei, Jinpeng Li, Cheguo Cai

Open access · diamondAbstract read
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Meng XuDepartment of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University; Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan 430071, China.
Anyi ChengDepartment of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University; Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan 430071, China.
Liya YuDepartment of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University; Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan 430071, China.
Wei WeiDepartment of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University; Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan 430071, China.
Jinpeng LiDepartment of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Cheguo CaiDepartment of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University; Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan 430071, China.
Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adenocarcinoma is the second largest histological type of cervical cancer, second only to cervical squamous cell carcinoma. At present, despite the clinical treatment strategies of cervical adenocarcinoma and cervical squamous cell carcinoma being similar, the outcome and prognosis of cervical adenocarcinoma are significantly poor. Therefore, it is urgent to find specific biomarker and therapeutic target for cervical adenocarcinoma. In this study, we aim to reveal and verify the potential biomarkers and therapeutic targets of cervical adenocarcinoma. Weighted correlation network analysis (WGCNA) reveals the differentially-expressed genes significantly related to the histological characteristics of the two cervical cancer subtypes. We select the genes with the top 20 significance for further investigation. Through microarray and immunohistochemical (IHC) analyses of a variety of tumor tissues, we find that among these 20 genes,

Indexed as

AdenocarcinomaBiomarkers, TumorCarcinoma, Squamous CellMolecular Targeted TherapyUterine Cervical NeoplasmsCytoskeletal ProteinsFemaleHumansAHNAK2 protein, humanBiomarkers, TumorCytoskeletal ProteinsadenocarcinomaAHNAK2squamous carcinomaWGCNA

Identifiers

PMID36017889
PMCPMC9828698
OpenAlexW4291367075

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.