Evidence map›Paper›PMID 36017888›Full record

ArticleActa biochimica et biophysica Sinica2022

N-acetyldopamine dimer inhibits neuroinflammation through the TLR4/NF-κB and NLRP3/Caspase-1 pathways.

Lijun Huang, Leiqiang Gong, Xueyan Huo, Lirong Lei, Qi Zhang, Yunjie Hu, Qixuan Kuang, Yu Gui, Yifei Dai, Yucheng Gu and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Lijun HuangState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Leiqiang GongState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Xueyan HuoState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Lirong LeiState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Qi ZhangState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Yunjie HuState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Qixuan KuangState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Yu GuiState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Yifei DaiDepartment of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
Yucheng GuSyngenta Jealott's Hill International Research Centre, Berkshire RG426EY, UK.
Yun DengState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Dong WangState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Dale GuoState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Chengdu University of Traditional Chinese Medicine · CNSyngenta (United Kingdom) · GBTsinghua University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroinflammation mediated by microglia is an important pathophysiological mechanism in neurodegenerative diseases. However, there is a lack of effective drugs to treat neuroinflammation. N-acetyldopamine dimer (NADD) is a natural compound from the traditional Chinese medicine

Indexed as

NF-kappa BToll-Like Receptor 4Aspartic AcidCaspasesDopamineHumansInterleukin-6LipopolysaccharidesMicrogliaMolecular Docking SimulationNeuroinflammatory DiseasesNLR Family, Pyrin Domain-Containing 3 ProteinPeptide HydrolasesReactive Oxygen SpeciesTumor Necrosis Factor-alphaAspartic AcidCaspasesDopamineInterleukin-6LipopolysaccharidesN-acetyldopamineNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinPeptide HydrolasesReactive Oxygen SpeciesTLR4 protein, humanToll-Like Receptor 4Tumor Necrosis Factor-alphaN-acetyldopamine dimerneuroinflammationNLRP3/Caspase-1 pathwaysurface plasmon resonance assayTLR4/NF-κB pathway

Identifiers

PMID36017888
PMCPMC10157536
OpenAlexW4292236271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.