Evidence map›Paper›PMID 36017568›Full record

ArticleEuropean heart journal2022

2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS).

Alexander R Lyon, Teresa López-Fernández, Liam S Couch, Riccardo Asteggiano, Marianne C Aznar, Jutta Bergler-Klein, Giuseppe Boriani, Daniela Cardinale, Raul Cordoba, Bernard Cosyns and 21 more

Erratum issued 9 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in European heart journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 9 registered trials, which are not on this map. Cited by 1,827 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,827citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05976893 phase4unknown statusstarted 2023, after this paper: background citation

Study on the Composite Endpoint Event of PCSK9 Inhibitor in Patients With Very High Risk of ASCVD and Cancer

Ran2023Enrolled620Registered outcomes5Posted comparisons0ConditionsASCVD, Atherosclerotic Cardiovascular Disease, Cancer, Proprotein Convertase Subtilisin/Kexin Type 9 InhibitorArmsEvolocumab, Statin
Open the trial in the graph
NCT06005259 phase4unknown statusnot on this mapstarted 2023, after this paper: background citation

Effect of Spironolactone in the Prevention of Anthracycline-induced Cardiotoxicity: a Randomized Clinical Trial (SPIROTOX Trial)

TypeinterventionalSponsorUniversity of Sao PauloRan2023 to 2025Enrolled264ConditionsCardiotoxicity, Neoplasms, Chemotherapy Effect, Heart FailureArmsSpironolactone, Placebo
NCT06086132 recruitingnot on this mapstarted 2025, after this paper: background citation

Detection and Prevention of Cancer-Related Cardiovascular Toxicity Registry (ISACS CARDIONCO-PREDICT)

Typeobservational_patient_registrySponsorUniversity of BolognaRan2025 to 2026Enrolled10,000ConditionsCancer Related Cardiovascular ToxicityArmsProspective validation of the HFA-ICOS risk score in a subset of subjects with newly diagnosed breast cancer and undergoing treatment with anthracyclines analogues with or without radiotherapy
NCT06130709 unknown statusnot on this mapstarted 2023, after this paper: background citation

IRAF-ABLATION Study: a Multicenter International Retrospective Cohort of Patients With BTK Inhibitors-related AF Treated by Catheter Ablation

TypeobservationalSponsorUniversity Hospital, CaenRan2023 to 2025Enrolled100ConditionsBTKi-induced Atrial Fibrillation, Hematologic Malignancy, Atrial Fibrillation Catheter AblationArmsAtrial fibrillation catheter ablation in a population of BTKi-induced atrial fibrillation
NCT06163924 recruitingnot on this mapstarted 2023, after this paper: background citation

To Investigate the Effect of Multidisciplinary Care Approach on Cardiovascular Risk Modification in Prostate Cancer Patients Receiving Androgen Deprivation Therapy

TypeobservationalSponsorChinese University of Hong KongRan2023 to 2029Enrolled130ConditionsCardiovascular Risk, Prostate Cancer
NCT06672120 narecruitingnot on this mapstarted 2025, after this paper: background citation

Exercise in Regional Breast Cancer With Neoadjuvant Anthracycline- Based Chemotherapy and Immunotherapy With Checkpoint-Inhibition

TypeinterventionalSponsorTechnical University of MunichRan2025 to 2028Enrolled120ConditionsCancer, BreastArmsExercise training
NCT06881940 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Rationale and Design of a Cardiac Rehabilitation Program on the Prevention of Cardiotoxicity in Breast Cancer Patients Undergoing Treatment With Anthracyclines and/or Trastuzumab: A Randomized, Active Control Group, Open-Label Trial

TypeinterventionalSponsorInstituto Nacional de Cardiologia Ignacio ChavezRan2025 to 2029Enrolled284ConditionsCancer Therapy-Related Cardiac DysfunctionArmsRehabilitation Program, No Rehabilitation Program
NCT07070765 narecruitingnot on this mapstarted 2025, after this paper: background citation

Sodium-glucose Transporter Type 2 Inhibition in Anthracycline-related Cardiotoxicity - SPRINT

TypeinterventionalSponsorUniversity of AberdeenRan2025 to 2028Enrolled70ConditionsBreast CancerArmsSodium-glucose transport-2 (SGLT-2) inhibitors, Standard medical treatment
NCT07588425 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Prospective and Molecular Biomarker-Based Evaluation of Cardiac Side Effects in Patients With Early-Stage Breast Cancer Receiving Systemic Therapy: A Single-Center Observational Cohort Study

TypeobservationalSponsorFatih GURLERRan2026 to 2028Enrolled100ConditionsBreast Cancer (Early Breast Cancer), Cardiotoxicity, Cancer Therapy-Related Cardiac Dysfunction
3 · Its place in the literature

Who cites it

1,827 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Structured exercise and cardiac outcomes during anthracycline or anti-HER2 therapy in breast cancer: systematic review and meta-analysis of randomized trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  2. Pooled it
  3. Exercise for the mitigation of cancer therapy-related cardiac dysfunction in breast cancer patients treated with anthracyclines: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Synthesis of clinical practice guidelines and recommendations for breast cancer survivorship care: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Association between comorbidity burden and subclinical cardiac dysfunction in cancer patients prior to chemotherapy.Hong Kong physiotherapy journal : official publication of the Hong Kong Physiotherapy Association Limited = Wu li chih liao · 2026
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. The Immune Checkpoint Inhibitors Journey: From Early Promise to Lasting Impact.Journal of immunotherapy and precision oncology · 2026
    Review
  19. Article
  20. Stratifying Cardiovascular Risk in Patients With HCC Receiving Atezolizumab/Bevacizumab: A Comparison of ESC and CARDIOSOR Scores.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Article

1,767 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors.

Alexander R Lyon(United Kingdom).
Teresa López-Fernández(Spain).
Liam S Couch(United Kingdom).
Riccardo Asteggiano(Italy).
Marianne C Aznar(United Kingdom).
Jutta Bergler-Klein(Austria).
Giuseppe Boriani(Italy).
Daniela Cardinale(Italy).
Raul Cordoba(Spain).
Bernard Cosyns(Belgium).
David J Cutter(United Kingdom).
Evandro de Azambuja(Belgium).
Rudolf A de Boer(Netherlands).
Susan F Dent(United States of America).
Dimitrios Farmakis(Cyprus).
Sofie A Gevaert(Belgium).
Diana A Gorog(United Kingdom).
Joerg Herrmann(United States of America).
Daniel Lenihan(United States of America).
Javid Moslehi(United States of America).
Brenda Moura(Portugal).
Sonja S Salinger(Serbia).
Richard Stephens(United Kingdom).
Thomas M Suter(Switzerland).
Sebastian Szmit(Poland).
Juan Tamargo(Spain).
Paaladinesh Thavendiranathan(Canada).
Carlo G Tocchetti(Italy).
Peter van der Meer(Netherlands).
Helena J H van der Pal(Netherlands).
ESC Scientific Document Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic AgentsHematologyNeoplasmsRadiation OncologyHeartHumansMedical OncologyAntineoplastic AgentsAmyloid light-chain cardiac amyloidosisAndrogen deprivation therapyAnthracyclineArrhythmiasAtrial fibrillationBiomarkersCancerCancer survivorsCarcinoid syndromeCardiac magnetic resonanceCardiac tumourCardio-oncologyCardiotoxicityChemotherapyCoronary artery diseaseEchocardiographyFluoropyrimidineGuidelinesHaematopoietic stem cell transplantationHeart failureHormone therapyHypertensionImmunotherapyIschaemic heart diseaseMyocarditisPericardial diseaseProteasome inhibitorsPulmonary hypertensionQTc prolongationRadiotherapyRisk stratificationStrainThrombosisTrastuzumabValvular heart diseaseVascular endothelial growth factor inhibitors (VEGFi)Venous thromboembolism

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 3 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.