Evidence map›Paper›PMID 36017353›Full record

ArticleFrontiers in bioengineering and biotechnology2022

Construction of ultrasound-responsive urokinase precise controlled-release nanoliposome applied for thrombolysis.

Yongliang Fan, Li Liu, Fang Li, Hang Zhou, Yizhou Ye, Chunping Yuan, Hongli Shan, Wangfu Zang, Yu Luo, Sijing Yan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Yongliang FanDepartment of Cardio-Thoracic Surgery, Shanghai 10th People's Hospital, School of Clinical Medicine of Nanjing Medical University, Shanghai, China.
Li LiuDepartment of Ultrasound Medicine, Chongqing University Cancer Hospital, Chongqing, China.
Fang LiDepartment of Ultrasound Medicine, Chongqing University Cancer Hospital, Chongqing, China.
Hang ZhouDepartment of Ultrasound Medicine, Chongqing University Cancer Hospital, Chongqing, China.
Yizhou YeDepartment of Cardiovascular Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chunping YuanShanghai Engineering Technology Research Center for Pharmaceutical Intelligent Equipment, Shanghai Frontiers Science Center for Druggability of Cardiovascular Non-coding RNA, Institute for Frontier Medical Technology, Shanghai University of Engineering Science, Shanghai, China.
Hongli ShanShanghai Engineering Technology Research Center for Pharmaceutical Intelligent Equipment, Shanghai Frontiers Science Center for Druggability of Cardiovascular Non-coding RNA, Institute for Frontier Medical Technology, Shanghai University of Engineering Science, Shanghai, China.
Wangfu ZangDepartment of Cardio-Thoracic Surgery, Shanghai 10th People's Hospital, School of Clinical Medicine of Nanjing Medical University, Shanghai, China.
Yu LuoShanghai Engineering Technology Research Center for Pharmaceutical Intelligent Equipment, Shanghai Frontiers Science Center for Druggability of Cardiovascular Non-coding RNA, Institute for Frontier Medical Technology, Shanghai University of Engineering Science, Shanghai, China.
Sijing YanDepartment of Ultrasound, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China.
Chongqing Cancer Hospital · CNShanghai University · CNNanjing Medical University · CNFirst People's Hospital of Chongqing · CNShanghai First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urokinase is widely used in the dissolution of an acute pulmonary embolism due to its high biocatalytic effect. However, how to precisely regulate its dose, avoid the side effects of hemolysis or ineffective thrombolysis caused by too high or too low a dose, and seize the golden time of acute pulmonary embolism are the key factors for its clinical promotion. Therefore, based on the precise design of a molecular structure, an ultrasonic-responsive nanoliposome capsule was prepared in this paper. Singlet oxygen is continuously generated under the interaction of the ultrasonic cavitation effect and the sonosensitizer protoporphyrin, and the generated singlet oxygen will break the thiol acetone bond between the hydrophilic head and the hydrophobic tail of the liposome, and the lipid The body structure disintegrates rapidly, and the urokinase encapsulated inside is rapidly released, down-regulating the expression of fibrinogen in the body, and exerting a thrombolytic function. The

Indexed as

protoporphyrin (PPIX)pulmonary embolismsinglet oxygensonodynamicurokinase

Identifiers

PMID36017353
PMCPMC9396409
OpenAlexW4290755647

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.