Evidence map›Paper›PMID 36017180›Full record

ArticleFrontiers in neuroscience2022

Walking exercise alters pedunculopontine nucleus connectivity in Parkinson's disease in a dose-dependent manner.

Jiayue Cai, Aiping Liu, Yuheng Wang, Sun Nee Tan, Taylor Chomiak, Jacqueline Burt, Richard Camicioli, Bin Hu, Martin J McKeown, Fang Ba

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Jiayue CaiSchool of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China.
Aiping LiuDepartment of Electronic Science and Technology, University of Science and Technology of China, Hefei, China.
Yuheng WangSchool of Biomedical Engineering, The University of British Columbia, Vancouver, BC, Canada.
Sun Nee TanGraduate Program in Neuroscience, The University of British Columbia, Vancouver, BC, Canada.
Taylor ChomiakDepartment of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
Jacqueline BurtDivision of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Richard CamicioliDivision of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Bin HuDepartment of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
Martin J McKeownDivision of Neurology, Department of Medicine, The University of British Columbia, Vancouver, BC, Canada.
Fang BaDivision of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
University of British Columbia · CAUniversity of Alberta · CAUniversity of Calgary · CAUniversity of Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Gait disturbances are critical motor symptoms in Parkinson's disease (PD). The mechanisms of gait impairment in PD are not entirely understood but likely involve changes in the Pedunculopontine Nucleus (PPN), a critical locomotion center, and its associated connections. Exercise is universally accepted as helpful in PD, but the extent and intensity of exercise required for plastic changes are unclear. Methods: Twenty-seven PD subjects participated in a 3-month gait training intervention. Clinical assessments and resting-state functional magnetic resonance imaging were performed at baseline and 3 months after exercise. Functional connectivity of PPN was assessed by combining the methods of partial least squares, conditional dependence and partial correlation. In addition, paired t-tests were used to examine the effect of exercise on PPN functional connectivity and clinical measures, and Pearson's correlation was used to assess the association between altered PPN functional connectivity and clinical measures. Results: Exercise significantly improved Unified Parkinson's Disease Rating Scale-III (UPDRS-III). A significant increase in right PPN functional connectivity was observed after exercise, which did not correlate with motor improvement. However, the decrease in left PPN functional connectivity significantly correlated with the improvement in UPDRS-III and was linearly related to both number of walks and the duration of walks. In addition, exercise induced a significant increase in the laterality of PPN connectivity strength, which correlated with motor improvement. Conclusion: PPN functional connectivity is modifiable by walking exercise in both a dose-independent (right PPN and laterality of PPN connectivity strength) and dose-dependent (left PPN) manner. The PPN may contribute to pathological and compensatory processes in PD gait control. The observed gait improvement by walking exercise is most likely due to the reversal of the maladaptive compensatory mechanism. Altered PPN functional connectivity can be a marker for exercise-induced motor improvement in PD.

Indexed as

fMRIfunctional connectivityParkinson’s diseasepedunculopontine nucleuswalking exercise

Identifiers

PMID36017180
PMCPMC9397130
OpenAlexW4292402045

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.