ArticleFrontiers in neuroscience2022
Neural evidence for non-orofacial triggers in mild misophonia.
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 19 citations in OpenAlex.
- Differential brain responses to affective sounds in misophonia and hyperacusis: A task-based fMRI approach.Cognitive, affective & behavioral neuroscience · 2026Article
- Selective Disruption of Salience-Network Anterior Insula Connectivity in Misophonia: A Disorder-Specific Neural Signature.Human brain mapping · 2026Article
- The mediating role of emotional empathy in the relationship between adverse childhood experiences and misophonia: a structural equation modeling.Frontiers in psychology · 2026Article
- Regional gray matter volume is associated with motor imagery performance in children with and without developmental coordination disorder.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Clinical Considerations for Integrating Ethical Principles of Beneficence in the Development of Evidence-Based Interventions: The case of Pediatric Misophonia.Research on child and adolescent psychopathology · 2025Review
- The Impact of Disgusting Sounds on Pupil Diameter of Misophonic and Non-Misophonic Listeners.Psychophysiology · 2025Article
- Understanding the misophonic experience: a mixed method study.Frontiers in psychology · 2025Article
- Examining the role of emotion regulation, anger, and anxiety in misophonia: A network model.PloS one · 2025Article
- A social cognition perspective on misophonia.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Misophonia reactions in the general population are correlated with strong emotional reactions to other everyday sensory-emotional experiences.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Brain circuits in autonomous sensory meridian response and related phenomena.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Hyperacusis in Tinnitus Individuals Is Associated with Smaller Gray Matter Volumes in the Supplementary Motor Area Regardless of Hearing Levels.Brain sciences · 2024Article
- The effect of misophonia on cognitive and social judgments.PloS one · 2024Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Misophonia, an extreme aversion to certain environmental sounds, is a highly prevalent yet understudied condition plaguing roughly 20% of the general population. Although neuroimaging research on misophonia is scant, recent work showing higher resting-state functional connectivity (rs-fMRI) between auditory cortex and orofacial motor cortex in misophonia vs. controls has led researchers to speculate that misophonia is caused by orofacial mirror neurons. Since orofacial motor cortex was defined using rs-fMRI, we attempted to theoretically replicate these findings using orofacial cortex defined by task-based fMRI instead. Further, given our recent work showing that a wide variety of sounds can be triggering (i.e., not just oral/nasal sounds), we investigated whether there is any neural evidence for misophonic aversion to non-orofacial stimuli. Sampling 19 adults with varying misophonia from the community, we collected resting state data and an fMRI task involving phoneme articulation and finger-tapping. We first defined "orofacial" cortex in each participant using rs-fMRI as done previously, producing what we call resting-state regions of interest (rsROIs). Additionally, we functionally defined regions (fROIs) representing "orofacial" or "finger" cortex using phoneme or finger-tapping activation from the fMRI task, respectively. To investigate the motor specificity of connectivity differences, we subdivided the rsROIs and fROIs into separate sensorimotor areas based on their overlap with two common atlases. We then calculated rs-fMRI between each rsROI/fROI and
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