Evidence map›Paper›PMID 36017165›Full record

ArticleFrontiers in chemistry2022

Refined Chelator Spacer Moieties Ameliorate the Pharmacokinetics of PSMA-617.

José Carlos Dos Santos, Martin Schäfer, Ulrike Bauder-Wüst, Barbro Beijer, Matthias Eder, Karin Leotta, Christian Kleist, Jan-Philip Meyer, Thomas R Dilling, Jason S Lewis and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

José Carlos Dos SantosDepartment of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany.
Martin SchäferResearch Group Molecular Biology of Systemic Radiotherapy, German Cancer Research Center, Heidelberg, Germany.
Ulrike Bauder-WüstResearch Group Molecular Biology of Systemic Radiotherapy, German Cancer Research Center, Heidelberg, Germany.
Barbro BeijerDepartment of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany.
Matthias EderDepartment of Nuclear Medicine, Division of Radiopharmaceutical Development, University Medical Center, University of Freiburg, Freiburg, Germany.
Karin LeottaClinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany.
Christian KleistDepartment of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany.
Jan-Philip MeyerDepartment of Radiology and the Program in Pharmacology, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Thomas R DillingDepartment of Radiology and the Program in Pharmacology, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Jason S LewisDepartment of Radiology and the Program in Pharmacology, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Clemens KratochwilDepartment of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany.
Klaus KopkaInstitute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.
Uwe HaberkornDepartment of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany.
Walter MierDepartment of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany.
University Hospital Heidelberg · DEMemorial Sloan Kettering Cancer Center · USGerman Cancer Research Center · DEHeidelberg University · DEHelmholtz-Zentrum Dresden-Rossendorf · DE

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Leveraging Pb-203/212 for the Theranostic Imaging and Therapy of Prostate CancerR35CA232130 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S. · 2019 to 2025
$8.2M
NCI NIH HHS P30 CA008748NCI NIH HHS R35 CA232130
6 · The paper itself

Abstract

Prostate-specific membrane antigen (PSMA) binding tracers are promising agents for the targeting of prostate tumors. To further optimize the clinically established radiopharmaceutical PSMA-617, novel PSMA ligands for prostate cancer endoradiotherapy were developed. A series of PSMA binding tracers that comprise a benzyl group at the chelator moiety were obtained by solid-phase synthesis. The compounds were labeled with

Indexed as

chelatorendoradiotherapyPET imagingprostate cancerPSMA

Identifiers

PMID36017165
PMCPMC9396645
OpenAlexW4292360100

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.