Evidence map›Paper›PMID 36017163›Full record

ReviewFrontiers in chemistry2022

Fluorinated triazoles as privileged potential candidates in drug development-focusing on their biological and pharmaceutical properties.

Ihsan Ullah, Muhammad Ilyas, Muhammad Omer, Muhammad Alamzeb, Adnan, Muhammad Sohail

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ihsan UllahInstitute of Chemical Sciences, University of Swat, Swat, Pakistan.
Muhammad IlyasInstitute of Chemical Sciences, University of Swat, Swat, Pakistan.
Muhammad OmerInstitute of Chemical Sciences, University of Swat, Swat, Pakistan.
Muhammad AlamzebDepartment of Chemistry, University of Kotli, Kotli, Pakistan.
AdnanInstitute of Chemical Sciences, University of Swat, Swat, Pakistan.
Muhammad SohailInstitute of Chemical Sciences, University of Swat, Swat, Pakistan.
University of Swat · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fluorinated heterocycles have attracted extensive attention not only in organic synthesis but also in pharmaceutical and medicinal sciences due to their enhanced biological activities than their non-fluorinated counterparts. Triazole is a simple five-membered heterocycle with three nitrogen atoms found in both natural and synthetic molecules that impart a broad spectrum of biological properties including but not limited to anticancer, antiproliferative, inhibitory, antiviral, antibacterial, antifungal, antiallergic, and antioxidant properties. In addition, incorporation of fluorine into triazole and its derivatives has been reported to enhance their pharmacological activity, making them promising drug candidates. This mini-review explores the current developments of backbone-fluorinated triazoles and functionalized fluorinated triazoles with established biological activities and pharmacological properties.

Indexed as

1,2,3-traizoles1,2,4-triazolesantibacterialanticancerantiviralbiological propertiesfluorinatedinhibitory

Identifiers

PMID36017163
PMCPMC9395585
OpenAlexW4290738888

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.