Evidence map›Paper›PMID 36017109›Full record

ArticleMaterials today. Bio2022

Biomimetic semiconducting polymer dots for highly specific NIR-II fluorescence imaging of glioma.

Xiaoju Men, Xiaorui Geng, Zhe Zhang, Haobin Chen, Meng Du, Zhiyi Chen, Gang Liu, Changfeng Wu, Zhen Yuan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  4. Ultrabright NIR-II Nanoprobes forACS nanoscience Au · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaoju MenHunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Academician Workstation, Changsha Medical University, Changsha, 410219, China.
Xiaorui GengFaculty of Health Sciences, University of Macau, Macau SAR, 999078, China.
Zhe ZhangDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Haobin ChenDepartment of Biomedical Engineering, School of Basic Medical Sciences, Central South University, Changsha, 410013, China.
Meng DuInstitute of Medical Imaging, Hengyang Medical School, University of South China, Hengyang, China.
Zhiyi ChenInstitute of Medical Imaging, Hengyang Medical School, University of South China, Hengyang, China.
Gang LiuCenter for Molecular Imaging and Translational Medicine, Xiamen University, Xiamen, China.
Changfeng WuDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Zhen YuanFaculty of Health Sciences, University of Macau, Macau SAR, 999078, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioma with very short medium survival time consists of 80% of primary malignant types of brain tumors. The unique microenvironment such as the existence of the blood-brain barrier (BBB) makes the glioma theranostics exhibit low sensitivity in diagnosis, a poor prognosis and low treatment efficacy. Therefore, the development of multifunctional nanoplatform that can cross BBB and target the glioma is essential for the high-sensitivity detection and ablation of cancer cells. In this study, C6 cell membrane-coated conjugated polymer dots (Pdots-C6) were constructed for targeted glioma tumor detection. As a new kind of biomimetic and biocompatible nanoprobes, Pdots-C6 preserve the complex biological functions of natural cell membranes while possessing physicochemical properties for NIR-II fluorescence imaging of glioma. After encapsulating C6 cell membrane on the surface of conjugated Pdots, Pdots-C6 exhibited the most favorable specific targeting capabilities in vitro and in vivo. In particular, this pilot study demonstrates that biomimetic nanoparticles offer a potential tool to enhance specific targeting to the brain, hence improving glioma tumor detection accuracy.

Indexed as

Brain tumorCell membrane coated nanoparticlesConjugated polymersPolymer dotsSecond near-infrared imaging

Identifiers

PMID36017109
PMCPMC9395678

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.