ArticleFrontiers in cardiovascular medicine2022
Base excess is associated with the risk of all-cause mortality in critically ill patients with acute myocardial infarction.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 8 citations in OpenAlex.
- Base Excess and Beyond: Evolving Concepts in Acid-base Analysis.Turkish journal of anaesthesiology and reanimation · 2026Article
- Impact of base excess on mortality in patients with sepsis-associated acute kidney injury: insights from US Intensive Care Unit Cohort.International urology and nephrology · 2026Article
- Prognostic Value of Standard Base Excess in Sepsis-Associated Acute Kidney Injury: A Retrospective Cohort Study.International journal of nephrology · 2026Article
- Tendency to acidosis or alkalosis: Which one is associated with coronary artery disease?Journal of cardiovascular and thoracic research · 2025Article
- Prognostic value of lactate-to-hemoglobin ratio in nontraumatic critically ill patients presenting to the emergency department: a retrospective cohort study.BMC emergency medicine · 2025Observational
- Association between standard base excess and acute kidney injury in intensive care unit patients: a study based on the medical information mart for intensive care database.BMC nephrology · 2025Article
- Determining the reference values for arterial blood gas, electrolytes and acid-base in healthy male sheep of Iranian Shall breed.Veterinary research forum : an international quarterly journal · 2025Article
- Association of alactic base excess with in-hospital mortality in patients with acute myocardial infarction: a retrospective cohort study.BMC cardiovascular disorders · 2024Article
- Association between base excess and 28-day mortality in sepsis patients: A secondary analysis based on the MIMIC- IV database.Heliyon · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Base excess (BE) represents an increase or decrease of alkali reserves in plasma to diagnose acid-base disorders, independent of respiratory factors. Current findings about the prognostic value of BE on mortality of patients with acute myocardial infarction (AMI) are still unclear. The purpose of this study was to explore the prognostic significance of BE for short-term all-cause mortality in patients with AMI. Methods: A total of 2,465 patients diagnosed with AMI in the intensive care unit from the Medical Information Mart for Intensive Care III (MIMIC-III) database were included in our study, and we explored the association of BE with 28-day and 90-day all-cause mortality using Cox regression analysis. We also used restricted cubic splines (RCS) to evaluate the relationship between BE and hazard ratio (HR). The primary outcomes were 28-day and 90-day all-cause mortality. Results: When stratified according to quantiles, low BE levels at admission were strongly associated with higher 28-day and 90-day all-cause mortality. Multivariable Cox proportional hazard models revealed that low BE was an independent risk factor of 28-day all-cause mortality [HR 4.158, 95% CI 3.203-5.398 (low vs. normal BE) and HR 1.354, 95% CI 0.896-2.049 (high vs. normal BE)] and 90-day all-cause mortality [HR 4.078, 95% CI 3.160-5.263 (low vs. normal BE) and HR 1.369, 95% CI 0.917-2.045 (high vs. normal BE)], even after adjustment for significant prognostic covariates. The results were also consistent in subgroup analysis. RCS revealed an "L-type" relationship between BE and 28-day and 90-day all-cause mortality, as well as adjusting for confounding variables. Meanwhile, Kaplan-Meier survival curves were stratified by combining BE with carbon dioxide partial pressure (PaCO Conclusion: Our study revealed that low BE was significantly associated with 28-day and 90-day mortality in patients with AMI and indicated the value of stratifying the mortality risk of patients with AMI by BE.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.