SynthesisFrontiers in cardiovascular medicine2022
Outcomes of postoperative delirium in patients undergoing cardiac surgery: A systematic review and meta-analysis.
Synthesis in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Association Between Perioperative Sleep Disorders and Post-Operative Delirium in Cardiac Surgeries: A Systematic Review and Meta-Analysis.Journal of sleep research · 2026Pooled it
- Frailty and postoperative complications in elderly patients undergoing cardiac surgery: a systematic review and meta-analysis.BMC geriatrics · 2026Pooled it
- Dexmedetomidine for the prevention of postoperative delirium in patients undergoing cardiac surgery: a systematic review and meta-analysis with trial sequential analysis.BMC anesthesiology · 2025Pooled it
- Pooled it
- Evaluating oxygen reserve index-guided oxygenation for the prevention of postoperative delirium in elderly patients: a randomized controlled trial.Croatian medical journal · 2025Trial
- Presurgical Sleep-Wake Disturbance and Postoperative Delirium: A Prospective Cohort Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Frontal cortical neuroinflammation and circulating biomarkers following cardiopulmonary bypass in sheep.Intensive care medicine experimental · 2026Article
- [Daylight therapy in intensive care units: a review].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026Review
- The effect of intravenous low-dose steroids on post-operative delirium in older adult patients undergoing non-cardiac surgery: a retrospective cohort analysis.Journal of anesthesia · 2026Article
- Implementation and economic analysis of a perioperative brain healthcare bundle: a mixed-methods study.BMJ open · 2026Observational
- Preoperative lactate-to-albumin ratio and risk of postoperative delirium after cardiac surgery in older adults: a retrospective cohort study.BMC cardiovascular disorders · 2026Article
- Incidence, patterns, and factors associated with postoperative pulmonary complications in an ERAS cardiac surgery program: a 500-patient cohort study.Journal of anesthesia, analgesia and critical care · 2026Article
- Postoperative Delirium After Cardiac Surgery: Psychiatric Vulnerability, Biological Mechanisms, and Prevention Strategies.Medical sciences (Basel, Switzerland) · 2026Review
- A virtual reality-based multicomponent intervention program for preventing postoperative delirium in the intensive care unit for cardiac surgery patients: from evidence-based design to a pilot trial.Frontiers in medicine · 2026Article
- Shared molecular mechanisms between colorectal cancer and cardiovascular disease drive perioperative neurological vulnerability.Frontiers in genetics · 2026Article
- Association between perioperative optic nerve sheath diameter and postoperative delirium after Bentall surgery: a prospective observational study.Frontiers in medicine · 2026Article
- A simple ratio, a complex outcome: glucose-to-albumin ratio predicts delirium in ICU patients after cardiac surgery.BMC cardiovascular disorders · 2025Article
- Association between triglyceride-glucose index and postoperative delirium following cardiac surgery: a multicenter retrospective analysis.Lipids in health and disease · 2025Article
- Practical prognostic tools to predict the risk of postoperative delirium in older patients undergoing cardiac surgery: visual and dynamic nomograms.Journal of clinical monitoring and computing · 2025Article
- Case Report: Persistent delusional memories after postoperative delirium in a woman with complex cardiac surgical history.Frontiers in psychiatry · 2025Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Postoperative delirium (POD) is an acute brain dysfunction that is frequently observed in patients undergoing cardiac surgery. Increasing evidence indicates POD is related to higher mortality among cardiac surgical patients, but the results remain controversial. Moreover, a quantitative evaluation of the influence of POD on hospital days, intensive care unit (ICU) time, and mechanical ventilation (MV) time has not been performed. Objective: This study aimed to evaluate the correlation between POD and outcomes in patients undergoing cardiac surgery by a systematic review and meta-analysis. Materials and methods: A total of 7 electronic databases (Cochrane Library, PubMed, EMBASE, CINAHL Complete, MEDLINE, Wan-fang database, and China National Knowledge Infrastructure) were searched from January 1980 to July 20, 2021, with language restrictions to English and Chinese, to estimate the impact of the POD on outcome in patients who underwent cardiac surgery. The meta-analysis was registered with PROSPERO (Registration: CRD42021228767). Results: Forty-two eligible studies with 19785 patients were identified. 3368 (17.0%) patients were in the delirium group and 16417 (83%) were in the non-delirium group. The meta-analysis showed that compared to patients without POD, patients with POD had 2.77-fold higher mortality (OR = 2.77, 95% CI 1.86-4.11, Conclusion: The synthesized evidence suggests that POD is causally related to the increased risk of mortality, prolonged length of ICU and hospital stay, and a longer duration of MV time. Future research should focus on the interventions for POD, to reduce the incidence. Systematic review registration: [www.crd.york.ac.uk/PROSPERO], identifier [CRD42021228767].
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.