Evidence map›Paper›PMID 36017025›Full record

ArticleContrast media & molecular imaging2022

Application of Fluorescence In Situ Hybridization Assisted by Fluorescence Microscope in Detection of Her2 Gene in Breast Cancer Patients.

Fang Lu, Tingting Zhou, Yan Liu, Liying Song, Bin Zhang, Yuyan Li

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in Contrast media & molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Fang LuJilin Kingmed for Clinical Laboratory Co, Ltd., Changchun, Jilin 130000, China.ORCID 0000-0003-2792-4580
Tingting ZhouJilin Kingmed for Clinical Laboratory Co, Ltd., Changchun, Jilin 130000, China.ORCID 0000-0002-9968-6916
Yan LiuJilin Kingmed for Clinical Laboratory Co, Ltd., Changchun, Jilin 130000, China.ORCID 0000-0002-6722-5269
Liying SongJilin Kingmed for Clinical Laboratory Co, Ltd., Changchun, Jilin 130000, China.ORCID 0000-0002-7812-5896
Bin ZhangJilin Kingmed for Clinical Laboratory Co, Ltd., Changchun, Jilin 130000, China.ORCID 0000-0002-2787-0087
Yuyan LiJilin Kingmed for Clinical Laboratory Co, Ltd., Changchun, Jilin 130000, China.ORCID 0000-0001-7923-3891
Kingmed Diagnostics · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In order to study the important factors for evaluating the prognosis of breast cancer patients, a fluorescence microscopy-assisted fluorescence in situ hybridization technique was proposed. Compared with other detection techniques, fluorescence in situ hybridization (FISH) technology assisted by a fluorescence microscope has gradually gained favor in related fields due to its advantages of high detection specificity, high sensitivity, and strong experimental period. Combined with the basic overview of fluorescence microscopy and FISH technology, the advantages and application points of FISH technology assisted by fluorescence microscopy in the detection of the Her2 gene in breast cancer patients were studied and discussed. The results show that IHC can be used as the primary screening for HER2 gene status detection; IHC (2+) and IHC (3+) have false positives, which are related to chromosome 17 polysomy, so FISH should be done to confirm the diagnosis.

Indexed as

Erb-b2 Receptor Tyrosine KinasesNeoplasmsGenes, erbB-2HumansIn Situ Hybridization, FluorescenceMicroscopy, FluorescenceErb-b2 Receptor Tyrosine Kinases

Identifiers

PMID36017025
PMCPMC9388259
OpenAlexW4291001352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.