Evidence map›Paper›PMID 36016956›Full record

ReviewFrontiers in immunology2022

Monoclonal antibody therapy of herpes simplex virus: An opportunity to decrease congenital and perinatal infections.

Iara M Backes, David A Leib, Margaret E Ackerman

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Developments in genital herpes: progress in prevention and treatment.Current opinion in infectious diseases · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Anti-HSV-1 agents: an update.Frontiers in pharmacology · 2024
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Iara M BackesDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States.
David A LeibDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States.
Margaret E AckermanThayer School of Engineering, Dartmouth College, Hanover, NH, United States.
Dartmouth College · US

Funding

VIral and host mechanisms that tilt the HSV lytic/latent balanceP01AI098681 · NIAID · HARVARD MEDICAL SCHOOL · PI PESOLA, JEAN M · 2013 to 2023
$19.2M
Transferred ImmunityU19AI145825 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PASETTI, MARCELA F · 2021 to 2025
$16.0M
VIRAL & HOST FACTORS IN HERPETIC REACTIVATIONR01EY009083 · NEI · WASHINGTON UNIVERSITY · PI David A Leib · 1992 to 2026
$10.3M
Monoclonal antibody therapy for neonatal HSV infectionsR21AI147714 · NIAID · DARTMOUTH COLLEGE · PI LEIB, DAVID A · 2019 to 2020
$451k
NEI NIH HHS R01 EY009083NIAID NIH HHS P01 AI098681NIAID NIH HHS R21 AI147714NIAID NIH HHS U19 AI145825
6 · The paper itself

Abstract

The fetal/neonatal period represents both a unique window of opportunity for interventions as well as vulnerability to a number of viral infections. While

Indexed as

Communicable DiseasesHerpes SimplexPregnancy Complications, InfectiousAdultAntibodies, MonoclonalFemaleHumansInfant, NewbornPlacentaPregnancySimplexvirusAntibodies, Monoclonaleffector functionherpes simplex virus (HSV) infectionIgGmonoclonal Abneonatal infection

Identifiers

PMID36016956
PMCPMC9398215
OpenAlexW4292452360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.